[Brain metastases-Interdisciplinary approach towards a personalized treatment]

Area of Science:

• Neuro-oncology
• Medical Oncology
• Radiation Oncology

Background:

• Brain metastases treatment has evolved significantly over recent decades.
• Historically, survival was limited (3-6 months), with palliative care often being the sole focus.
• Previous approaches often excluded patients from systemic therapy and clinical trials.

Purpose of the Study:

• To review the progress in treating brain metastases.
• To highlight the complexity of modern interdisciplinary treatment concepts.
• To demonstrate advancements in personalized medicine for brain metastases.

Main Methods:

• Review of current literature on brain metastases management.
• Analysis of novel surgical, radiotherapeutic, and systemic treatment modalities.
• Discussion of interdisciplinary and personalized treatment strategies.

Main Results:

• Survival times for brain metastases have substantially increased.
• Targeted therapies, immunotherapies, and advanced radiation techniques are now available.
• Personalized treatment approaches are increasingly feasible.

Conclusions:

• Modern treatment paradigms have transformed brain metastases care.
• Interdisciplinary collaboration is crucial for optimal patient outcomes.
• Advancements enable more effective and tailored therapeutic strategies.