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Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

284
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
255
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
265
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
299
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
274
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

426
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Updated: Nov 4, 2025

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

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New Therapeutics for Ulcerative Colitis.

Robert P Hirten1, Bruce E Sands1

  • 1The Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; email: robert.hirten@mountsinai.org, bruce.sands@mssm.edu.

Annual Review of Medicine
|January 27, 2021
PubMed
Summary
This summary is machine-generated.

New ulcerative colitis (UC) treatments are emerging due to limited success with current options. This review highlights promising drugs and non-medication approaches for future UC management.

Keywords:
Crohn's diseaseanti-adhesion therapyanti-interleukin inhibitorinflammatory bowel diseasejanus kinase inhibitorsphingosine receptor modulatorulcerative colitis

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Area of Science:

  • Gastroenterology and immunology
  • Inflammatory bowel disease research

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory condition of the colon characterized by unpredictable relapses and remissions.
  • Current treatments achieve clinical remission in only about 40% of patients within a year, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To review and highlight emerging therapeutic approaches for ulcerative colitis (UC).
  • To explore novel drugs in development, strategies to enhance current treatments, and non-pharmacological interventions for UC.

Main Methods:

  • Comprehensive literature review of recent advancements in UC therapeutics.
  • Analysis of promising drug candidates across different developmental phases.
  • Evaluation of non-medication-based treatment modalities and strategies for optimizing existing therapies.

Main Results:

  • Identification of several novel drug candidates showing potential in preclinical and clinical studies.
  • Exploration of strategies to improve the efficacy and patient response to established UC treatments.
  • Discussion of non-pharmacological interventions, such as dietary modifications and lifestyle changes, as adjuncts to medical therapy.

Conclusions:

  • The future of ulcerative colitis management involves a multi-faceted approach, integrating novel pharmacological agents with optimized existing treatments and non-medication modalities.
  • Emerging therapies hold significant promise for improving clinical outcomes and achieving sustained remission in UC patients.