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Updated: Nov 19, 2025

Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
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Cleanroom Cleanliness.

Kyle Mulder1

  • 1Technical Safety Services, Berkeley, California. Kmulder@techsafety.com.

International Journal of Pharmaceutical Compounding
|January 27, 2021
PubMed
Summary
This summary is machine-generated.

Cleanroom technology has evolved to minimize airborne contaminants for sterile environments. Maintaining low particulate levels is crucial for contamination control during sterile compounding.

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Area of Science:

  • Environmental Science
  • Microbiology
  • Pharmaceutical Technology

Background:

  • Cleanroom technology has evolved over the last century to create highly restricted environments.
  • The primary goal is to minimize airborne and surface contaminants, especially for sterile compounding applications.
  • While complete sterility is unattainable, reducing particulate burden to acceptable levels is essential.

Purpose of the Study:

  • To review pivotal developments in cleanroom technology.
  • To discuss contamination control strategies within sterile compounding environments.
  • To examine factors influencing contamination levels in cleanrooms and present prevention methods.

Main Methods:

  • Historical review of cleanroom evolution.
  • Discussion of contamination control principles.

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  • Analysis of factors affecting cleanroom contamination.
  • Presentation of contamination prevention strategies.

    • Main Results:

    • Cleanroom standards have progressively tightened over the past century.
    • Airflow dynamics and surface deposition are key factors in particulate contamination.
    • Specific environmental factors significantly impact contamination levels in cleanroom suites.

    Conclusions:

    • Continuous evolution of cleanroom design and practices is necessary.
    • Effective contamination control is paramount for sterile compounding.
    • Implementing suggested prevention strategies can maintain acceptable particulate levels.