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Age-dependent histomorphometric evolution of the corpus spongiosum
Gino Pigatto Filho1, Marcelo Zeni2, Eduardo Felippe Melchioretto2
1Fellow Master degree, Postgraduate Program in Surgical Clinic, Universidade Federal do Paraná, Curitiba-PR, Brazil.
Acta Cirurgica Brasileira
|January 27, 2021
Summary
Aging in rats decreases elastic fiber volume and the ratio of collagen types I/III in the corpus spongiosum. Total collagen quantity remained unchanged with age.
Area of Science:
- Urology
- Histology
- Aging Research
Background:
- The corpus spongiosum's structural integrity is vital for erectile function.
- Age-related changes in its extracellular matrix components are not fully understood.
Purpose of the Study:
- To investigate age-dependent alterations in elastic fibers, collagen fibers, and collagen types I/III proportion within the rat corpus spongiosum.
Main Methods:
- Stereological analysis of penile histological sections from rats aged 6, 9, 12, and 24 months.
- Staining techniques included Weigert's resorcin-fuchsin, Masson's trichrome, and Picrosirius red.
Main Results:
- A significant decrease in the collagen types I/III proportion was observed in older rats (24 months).
- Elastic fiber volume increased between 9 and 12 months, then decreased significantly by 24 months.
- No significant age-related changes were found in the total collagen quantity.
Conclusions:
- Aging reduces elastic fiber volume and the ratio of collagen types I/III in the rat corpus spongiosum.
- These changes may impact the functional properties of the corpus spongiosum with age.
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