Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sit-To-Stand Breaks to Optimize Cardiometabolic Health Effects Following Exercise in Sedentary Adults With Dyslipidaemia: A Randomized Crossover Trial.

Scandinavian journal of medicine & science in sports·2026
Same author

Cardiorespiratory Exercise Intensity Prescription in Cardiovascular Rehabilitation: Do Updated Guideline Recommendations Reflect Real Individual Effort Responses?

European journal of preventive cardiology·2026
Same author

Type 2 diabetes is related to neurochemical alterations in the default mode network: An exploratory cross-sectional magnetic resonance spectroscopy study.

NeuroImage·2026
Same author

Optimizing physical activity bouts to interrupt sedentary behaviour for cardiometabolic health: a systematic review and meta-analyses of randomized controlled trials.

European journal of preventive cardiology·2026
Same author

Adipose tissue-derived extracellular vesicles as drivers of endothelial dysfunction in obesity.

Trends in endocrinology and metabolism: TEM·2026
Same author

Effects of reducing sedentary behaviour on cardiovascular health, skeletal muscle oxidative capacity and functional exercise capacity in sedentary adults: a randomised controlled trial.

BMJ open sport & exercise medicine·2026

Related Experiment Video

Updated: Nov 19, 2025

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

17.1K

Periodized versus classic exercise therapy in Multiple Sclerosis: a randomized controlled trial.

Charly Keytsman1, Pieter Van Noten1, Kenneth Verboven1

  • 1REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium; BIOMED Biomedical Research Institute, Hasselt University, Agoralaan Building A, B-3590, Diepenbeek, Belgium.

Multiple Sclerosis and Related Disorders
|January 27, 2021
PubMed
Summary

Periodized exercise training in Multiple Sclerosis (MS) significantly improved exercise capacity more than classic training, despite a 57% reduction in training time. This suggests periodization may be a more effective approach for MS rehabilitation.

Keywords:
High intensity interval trainingMultiple sclerosisPeriodisationRehabilitation

More Related Videos

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
08:53

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

1.1K
Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
07:20

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy

Published on: August 9, 2024

1.5K

Related Experiment Videos

Last Updated: Nov 19, 2025

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

17.1K
Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
08:53

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

1.1K
Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
07:20

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy

Published on: August 9, 2024

1.5K

Area of Science:

  • Exercise physiology and rehabilitation science.
  • Neurological disorders and physical therapy.

Background:

  • Periodized exercise interventions in Multiple Sclerosis (MS) demonstrate good adherence for high-intensity training.
  • The comparative effectiveness of periodized versus linear progressive training on exercise capacity, body composition, and muscle strength in MS remains unknown.

Purpose of the Study:

  • To compare the effects of a 12-week periodized exercise program versus a classic endurance training program on exercise capacity in individuals with MS.
  • To evaluate adaptations in body composition and muscle strength between the two training modalities.

Main Methods:

  • Thirty-one individuals with MS were randomized into either a periodized (MSPER) or classic endurance (MSCLA) training group for 12 weeks.
  • Assessments included maximal exercise testing (VO2max), body composition (DEXA), and muscle strength (Biodex®) at baseline and post-intervention.
  • Periodized training involved cycles of endurance, high-intensity sprints, and recovery, while classic training consisted of moderate-intensity cycling.

Main Results:

  • The periodized group (MSPER) achieved significantly greater improvements in VO2max (+14%) compared to the classic group (MSCLA, +5%), despite 57% less peak-effort training time.
  • Both groups showed significant improvements in workload and time until exhaustion, with MSPER demonstrating larger gains (+20% vs. +10% workload; +25% vs. +17% time to exhaustion).
  • Pre-post improvements in VO2max were significantly higher in the MSPER group compared to the MSCLA group (p=0.046).

Conclusions:

  • Twelve weeks of periodized exercise training in individuals with MS induces superior improvements in exercise capacity compared to classic endurance training, even with substantially reduced training volume.
  • Periodization may offer a more time-efficient and effective strategy for improving functional rehabilitation outcomes in MS.
  • Further research is recommended to explore the impact of training periodization on diverse functional rehabilitation measures in MS.