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Comprehensive Review on the Clinical Relevance of Long Non-Coding RNAs in Cutaneous Melanoma

Vincenzo De Falco1, Stefania Napolitano1, Daniela Esposito2

  • 1Department of Precision Medicine, Università della Campania "Luigi Vanvitelli", 80131 Napoli, Italy.

International Journal of Molecular Sciences
|January 28, 2021
PubMed

Insights

Long non-coding RNAs (lncRNAs) are emerging as key players in melanoma, offering potential as diagnostic, prognostic, and therapeutic targets. This review explores their diverse roles in melanoma, addressing resistance to current treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cutaneous melanoma incidence is rising, with resistance to targeted therapies and immunotherapy posing challenges.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their regulatory roles in cancer.
  • lncRNAs are differentially expressed in tumors, suggesting potential as biomarkers and therapeutic targets.

Purpose of the Study:

  • To review the existing literature on the role of lncRNAs in melanoma.
  • To elucidate the potential functions of lncRNAs in melanoma development and progression.
  • To highlight lncRNAs as potential biomarkers and therapeutic targets in melanoma.

Main Methods:

  • Comprehensive literature search for studies on lncRNAs in melanoma.
  • Analysis of identified literature to synthesize findings on lncRNA functions.
  • Review of lncRNA roles in melanoma pathogenesis, diagnosis, prognosis, and treatment resistance.

Main Results:

  • lncRNAs are implicated in various aspects of melanoma, including cell proliferation, migration, and invasion.
  • Specific lncRNAs have been identified as potential diagnostic and prognostic biomarkers.
  • lncRNAs may contribute to resistance mechanisms against BRAF/MEK inhibitors and immunotherapy.

Conclusions:

  • lncRNAs represent a promising area of research in melanoma.
  • Further investigation into lncRNAs could lead to novel diagnostic and therapeutic strategies for melanoma patients.
  • Targeting lncRNAs may help overcome resistance to current melanoma treatments.
Keywords:
biomarkerscancer therapylncRNAmelanomaskin cancer

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