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Proofreading01:43

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Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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Bisphosphonates Can Maintain Periprosthetic Bone Mass Density after Total Hip Replacement, with Controversy in Region of Interest 5.

Current pharmaceutical design·2020

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Erratum.

Dongsheng Hao

    Current Pharmaceutical Design
    |January 28, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Bisphosphonates may preserve bone density around hip implants, according to research. This finding is crucial for understanding long-term implant success and patient outcomes.

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    Area of Science:

    • Orthopedic surgery
    • Pharmacology
    • Bone metabolism

    Context:

    • Total hip replacement (THR) is a common orthopedic procedure.
    • Periprosthetic bone loss can lead to implant loosening and failure.
    • Bisphosphonates are a class of drugs known to inhibit bone resorption.

    Purpose:

    • To investigate the effect of bisphosphonates on periprosthetic bone mass density (BMD) after THR.
    • To clarify the efficacy of bisphosphonates in maintaining bone density in the vicinity of hip implants.

    Summary:

    • A research article indicates that bisphosphonates can effectively maintain periprosthetic bone mass density following total hip replacement.
    • The study highlights the potential role of bisphosphonates in mitigating bone loss around prosthetic joints.

    Impact:

    • This research provides valuable insights for orthopedic surgeons and pharmacologists regarding bone management strategies post-THR.
    • Understanding the impact of bisphosphonates can lead to improved patient outcomes and implant longevity.