Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

264
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
264
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

1.2K
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inter-Rater Reliability Of Assigning A Pediatric Appendicitis Grade: An International Multicenter Study By The Canadian Consortium For Research In Pediatric Surgery (CanCORPS).

Annals of surgery open : perspectives of surgical history, education, and clinical approaches·2026
Same author

Inflammasome-Primed Neutrophils Aggravate Atherosclerosis in Cigarette Smoking.

Circulation research·2026
Same author

Targeting hypothalamic SIK3 to promote weight loss and improve glycemic control in mice.

Nature communications·2026
Same author

The roles of free-fatty acid receptors in the pathophysiology of renal disorders.

The Journal of pharmacology and experimental therapeutics·2026
Same author

Appetite for destruction: dietary lipids tune the ferroptotic threshold of adaptive immunity.

Immunology and cell biology·2026
Same author

β2 adrenergic receptors orchestrate neutrophil demargination and recruitment to the ischemic heart following myocardial infarction.

Nature communications·2026

Related Experiment Video

Updated: Nov 19, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

10.4K

Appendectomy Versus Observation for Appendicitis in Neutropenic Children With Cancer.

Benjamin T Many1, Timothy B Lautz1, Sarah Dobrozsi2

  • 1Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Chicago, Illinois.

Pediatrics
|January 28, 2021
PubMed
Summary

Upfront appendectomy for neutropenic appendicitis (NA) in pediatric cancer patients is linked to fewer complications and shorter hospital stays. Initial nonoperative management may delay cancer treatment and increase risks.

More Related Videos

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
08:26

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Published on: March 24, 2023

957
Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults
04:14

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults

Published on: February 28, 2025

420

Related Experiment Videos

Last Updated: Nov 19, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

10.4K
Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
08:26

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Published on: March 24, 2023

957
Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults
04:14

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults

Published on: February 28, 2025

420

Area of Science:

  • Pediatric Surgery
  • Pediatric Oncology
  • Surgical Outcomes

Background:

  • Neutropenic appendicitis (NA) management in pediatric cancer patients lacks clear guidelines.
  • Treatment options include upfront appendectomy or initial nonoperative management.
  • The optimal strategy impacts patient outcomes and cancer therapy.

Purpose of the Study:

  • To compare the effects of upfront appendectomy versus initial nonoperative management for NA in pediatric cancer patients.
  • To analyze complications, length of stay (LOS), and chemotherapy alterations based on management strategy.
  • To provide evidence for optimizing NA treatment in this vulnerable population.

Main Methods:

  • Retrospective review of pediatric patients with NA undergoing cancer treatment.
  • Data collected from sites within the Pediatric Surgery Oncology Research Collaborative over a 6-year period.
  • Comparison of outcomes between upfront appendectomy and initial nonoperative management groups.

Main Results:

  • Upfront appendectomy was performed in 41% of 66 pediatric NA patients; most had leukemia or brain tumors.
  • Initial nonoperative management led to a higher rate of cancer treatment delay (46% vs. 22%) and longer LOS (29 vs. 12 days).
  • Patients managed nonoperatively with delayed appendectomy experienced increased postoperative complications.

Conclusions:

  • Upfront appendectomy is associated with better outcomes in pediatric NA patients undergoing cancer therapy.
  • This approach reduces complication rates, shortens hospital stays, and minimizes chemotherapy regimen alterations.
  • Initial nonoperative management may negatively impact cancer treatment timelines and patient recovery.