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Esterase D polymorphism in Serbia (Yugoslavia).

Z Lemić¹, V Kalimanovska, Z Jelić-Ivanović

¹Department of Biochemistry, Faculty of Pharmacy, University of Belgrade, Yugoslavia.

|January 1, 1988

Summary

Red blood cell esterase D (EsD) phenotypes were analyzed in Serbian adults. The study found allele frequencies of EsD1 (0.911) and EsD2 (0.089), aligning with genetic equilibrium expectations.

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Area of Science:

Biochemistry
Human Genetics
Population Genetics

Background:

Esterase D (EsD) is a human enzyme encoded by a polymorphic gene.
Understanding EsD allele frequencies is crucial for population genetics and forensic science.
Previous studies have established EsD phenotypes in various global populations.

Purpose of the Study:

To determine the phenotype and allele frequencies of red cell esterase D (EsD) in a Serbian (Yugoslavian) population.
To compare these findings with existing data from other ethnic groups.
To assess the genetic structure of the studied population regarding the EsD locus.

Main Methods:

Blood samples were collected from 351 unrelated adult individuals from Serbia.
Esterase D phenotypes were determined using established electrophoretic techniques.
Allele frequencies were calculated based on observed phenotype distributions.

Main Results:

The most common EsD phenotype observed was EsD 1-1.
The calculated allele frequencies were EsD1 = 0.911 and EsD2 = 0.089.
The observed phenotype distribution closely matched the expected Hardy-Weinberg equilibrium.

Conclusions:

The Serbian population exhibits a genetic profile for esterase D consistent with other European populations.
The EsD locus appears to be in Hardy-Weinberg equilibrium in this sample.
These frequency data contribute to the global database of human genetic variation for esterase D.

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