Related Experiment Video
Updated: Nov 19, 2025
Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds
Published on: September 8, 2021
Methicillin-Resistant Coagulase-Negative Staphylococci Carriage is a Protective Factor of Methicillin-Resistant
Ying Li1, Jialing Lin2, Linghua Li3
1Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
Background:
Methicillin-resistant coagulase-negative Staphylococci (MRCoNS) is regarded as the repository of mecA gene for methicillin-resistant Staphylococcus aureus (MRSA) and may develop methicillin-susceptible Staphylococcus aureus (MSSA) to MRSA. Therefore, we aimed to explore whether MRCoNS carriage is a risk factor of MRSA colonization. Phenotypic characteristics were performed to further assess the associations between MRSA and MRCoNS.
Methods:
This cross-sectional study was conducted in Guangzhou, China. Participants completed a questionnaire and provided a nasal swab for further analysis. The risk factors of MRSA colonization were analyzed using nonconditional logistic regression models. The phenotypic characteristics between MRSA and MRCoNS were compared by Chi-square test.
Results:
Among the 1001 HIV-infected patients, a total of 119 (11.89%) participants were positive for MRSA, and 34.45% (41/119) of all MRSA carriers were positive for MRCoNS. We found MRCoNS carriage was a protective factor of MRSA colonization (adjusted odds ratio = 0.59, 95% confidence interval: 0.38-0.91). A significant difference in the proportions of antibiotic resistance between MRSA and MRCoNS isolates was found except for penicillin, clindamycin, tetracycline, and teicoplanin. The main STs and CC types of MRSA isolates in this population were ST188 (15.1%) and CC59 (17.6%), respectively.
Conclusions:
HIV-infected patients remain a highly vulnerable population for MRSA colonization. Though who carried MRCoNS is less likely to have MRSA colonization, similarity of some antibiotic resistance between MRSA and MRCoNS was found in this study. Regular surveillance on the colonization and antibiotic patterns of MRSA and MRCoNS is still necessary.
Insights
Methicillin-resistant coagulase-negative Staphylococci (MRCoNS) carriage may protect against methicillin-resistant Staphylococcus aureus (MRSA) colonization in HIV-infected patients. However, similarities in antibiotic resistance patterns necessitate ongoing surveillance for both strains.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- Methicillin-resistant coagulase-negative Staphylococci (MRCoNS) carry the mecA gene, potentially contributing to the development of methicillin-resistant Staphylococcus aureus (MRSA).
- Understanding the relationship between MRCoNS carriage and MRSA colonization is crucial, especially in vulnerable populations like HIV-infected individuals.
Purpose of the Study:
- To investigate whether MRCoNS carriage is a risk factor for MRSA colonization in HIV-infected patients.
- To analyze phenotypic characteristics and antibiotic resistance patterns of MRSA and MRCoNS.
Main Methods:
- A cross-sectional study involving 1001 HIV-infected patients in Guangzhou, China.
- Data collection included questionnaires and nasal swabs for bacterial analysis.
- Non-conditional logistic regression and Chi-square tests were used for statistical analysis.
Main Results:
- MRSA colonization was found in 11.89% of participants; 34.45% of MRSA carriers also had MRCoNS.
- MRCoNS carriage was identified as a protective factor against MRSA colonization (aOR=0.59).
- Significant differences in antibiotic resistance were observed between MRSA and MRCoNS, except for penicillin, clindamycin, tetracycline, and teicoplanin. ST188 and CC59 were the main MRSA types.
Conclusions:
- HIV-infected patients are a vulnerable group for MRSA colonization.
- While MRCoNS carriage appears protective, shared antibiotic resistance highlights the need for vigilance.
- Regular surveillance of MRSA and MRCoNS colonization and antibiotic resistance patterns is essential.
Related Concept Videos
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:20Sputum Studies II: Culture and Sensitivity
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
01:22Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...