Related Experiment Video

Updated: Nov 19, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

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Selective immunoglobulin M deficiency in a patient with celiac disease and recurrent pneumonia

Marziyeh Heidarzadeh Arani1, Mohsen Razavizadeh2,3, Reza ArefNezhad4,5

  • 1Department of Pediatrics Faculty of Medicine Kashan University of Medical Sciences Kashan Iran.

Clinical Case Reports
|January 28, 2021
PubMed

Insights

Selective IgA deficiency (SIgMD) is a rare immune disorder that can be primary or secondary. Patients experiencing recurrent infections, cancers, or autoimmune diseases warrant investigation for SIgMD.

Area of Science:

  • Immunology
  • Clinical Medicine

Background:

  • Selective IgA deficiency (SIgMD) is a primary immunodeficiency.
  • It can also manifest as a secondary condition.
  • SIgMD affects the adaptive immune system's antibody production.

Observation:

  • Patients with SIgMD often present with recurrent infections.
  • Malignancies, particularly gastrointestinal cancers, are associated with SIgMD.
  • Autoimmune disorders frequently co-occur with SIgMD.

Findings:

  • Recurrent infections, cancers, and autoimmune disorders are key indicators for SIgMD investigation.
  • Early identification of SIgMD is crucial for patient management.
  • The diagnostic pathway for SIgMD involves assessing immunoglobulin levels.

Implications:

  • Investigating SIgMD in at-risk populations can lead to earlier diagnosis and treatment.
  • Understanding the link between SIgMD and other disorders aids in comprehensive patient care.
  • Further research into the pathogenesis of SIgMD may reveal new therapeutic targets.
Keywords:
celiac diseaserecurrent pneumoniaselective IgM deficiency

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