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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Clinical Findings in Diabetes Mellitus Patients with COVID-19

Ting Guo1,2,3, Qinxue Shen1,2,3, Xiaoli Ouyang1,2,3

  • 1Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan 410011, China.

Journal of Diabetes Research
|January 28, 2021
PubMed

Insights

Diabetes mellitus (DM) patients with COVID-19 face higher risks of severe illness, particularly women. Elevated HbA1c and proteinuria indicate potential risk factors for severe coronavirus disease in these individuals.

Area of Science:

  • Infectious Diseases
  • Endocrinology
  • Critical Care Medicine

Background:

  • Diabetes mellitus (DM) is a frequent comorbidity in patients diagnosed with coronavirus disease (COVID-19).
  • Understanding the clinical characteristics of DM patients with COVID-19 is crucial for managing severe disease outcomes.

Purpose of the Study:

  • To summarize the clinical features of patients with DM and COVID-19.
  • To identify potential factors associated with severe COVID-19 disease in diabetic patients.

Main Methods:

  • A retrospective, single-center study reviewed medical records of COVID-19 patients in Changsha, China.
  • Compared epidemiological information, clinical features, and outcomes between DM and non-DM patients, focusing on ICU admission.

Main Results:

  • Out of 241 COVID-19 patients, 19 had DM. DM patients showed higher ICU admission rates (36.8% vs. 15.8%).
  • Female DM patients in the ICU were more prevalent (85.7% vs. 31.4%). Higher HbA1c (8.5% vs. 7.1%) and proteinuria (57.1% vs. 33.3%) were observed in ICU DM patients.
  • Most DM patients (63.2%) required changes in diabetic therapy; all ICU DM patients received insulin. All 19 DM patients were discharged without mortality.

Conclusions:

  • DM patients with COVID-19 are susceptible to severe disease, with female patients being particularly vulnerable.
  • Elevated HbA1c and proteinuria may serve as indicators for severe COVID-19 in DM patients.
  • Effective blood glucose control and appropriate diabetic management are vital for improving prognosis in severe cases.
Abstract

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