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Related Experiment Video

Updated: Nov 19, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Choroidal structural changes in different intermediate AMD patterns.

Pasquale Viggiano¹, Lisa Toto¹, Giada Ferro¹

¹Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, Chieti, Italy.

European Journal of Ophthalmology

|January 28, 2021

Summary

This summary is machine-generated.

Reticular pseudodrusen (RPD) eyes show significantly reduced choroidal thickness and vascularity compared to healthy eyes. This suggests RPD may lead to severe ischemia and hypoxia, increasing the risk of advanced age-related macular degeneration (AMD).

Keywords:

Retinal degenerations associated with systemic disease macular and RPE dystrophies retina - medical therapies retinal cell biology retinal pathology/research

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Last Updated: Nov 19, 2025

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Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Published on: February 19, 2014

Area of Science:

Ophthalmology
Medical Imaging
Retinal Diseases

Background:

Age-related macular degeneration (AMD) is a leading cause of vision loss.
Understanding choroidal changes in early AMD subtypes is crucial for risk stratification.
Reticular pseudodrusen (RPD) and drusen are distinct macular abnormalities associated with AMD.

Purpose of the Study:

To compare choroidal thickness (CT) and choroidal vascularity index (CVI) in individuals with RPD and drusen versus healthy controls.
To investigate the role of choroidal vascular alterations in RPD pathogenesis.

Main Methods:

A prospective, observational, cross-sectional study involving 84 participants.
Enhanced depth imaging (EDI) Spectral-domain Optical Coherence Tomography (SD-OCT) was used for imaging.
Semiautomated analysis of EDI-OCT images quantified CT and CVI in foveal, parafoveal, and perifoveal regions.

Main Results:

Choroidal thickness (CT) was significantly reduced in all analyzed regions for eyes with RPD compared to both drusen and healthy eyes (p < .005).
Choroidal vascularity index (CVI) was significantly decreased in the RPD pattern compared to healthy eyes (p < .001).
The drusenoid pattern did not show statistically significant differences in CT or CVI compared to controls.

Conclusions:

Significant differences in CT and CVI exist between RPD and drusenoid patterns.
RPD is associated with reduced choroidal vascularity, potentially leading to ischemia and hypoxia.
These findings suggest RPD may confer a higher risk of developing late AMD compared to the drusenoid pattern.