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Clinical Outcome of Guillain-Barré Syndrome in 108 Children
Sandip Sen1, Anil Kumar1, Banasree Roy2
1Dr BC Roy Postgraduate Institute of Pediatric Science, Kolkata,West Bengal.
Insights
Guillain-Barré syndrome (GBS) in children from Eastern India showed the demyelinating variety was more common. Most pediatric GBS patients recovered within six months, with better outcomes for the demyelinating subtype.
Area of Science:
- Pediatric Neurology
- Clinical Electrophysiology
Background:
- Guillain-Barré syndrome (GBS) is a rare autoimmune disorder affecting the peripheral nervous system.
- Understanding GBS subtypes and outcomes in pediatric populations is crucial for effective management.
Purpose of the Study:
- To investigate the clinical outcomes and electrophysiologic features of pediatric Guillain-Barré syndrome in Eastern India.
- To compare the recovery rates between demyelinating and axonal subtypes of GBS in children.
Main Methods:
- Retrospective review of hospital records for children under 12 diagnosed with GBS between November 2015 and December 2018.
- Disability assessment using the Hughes scale at 8-week and 6-month follow-ups.
Main Results:
- The demyelinating variety of GBS (52.8%) was more prevalent than the axonal variety (33.3%) in the studied pediatric cohort.
- A significant recovery rate of 71.1% (Hughes scale 0-1) was observed within 6 months post-diagnosis.
- Patients with the demyelinating subtype demonstrated a higher recovery rate (78.6%) compared to the axonal subtype (67.7%) at 6-month follow-up.
Conclusions:
- The demyelinating subtype of Guillain-Barré syndrome in children is associated with less disability compared to the axonal subtype, irrespective of initial severity.
- Early identification and subtype classification of pediatric GBS are important for predicting clinical outcomes.
Objectives:
To review the clinical outcome and electrophysiologic characteristics of children with Guillain-Barré syndrome (GBS) from Eastern India.
Methods:
The hospital records of the children aged less than 12 years with a final diagnosis of GBS at our hospital from November, 2015 to December, 2018 were reviewed. Disabilities were assessed at 8-weeks and 6-month follow-up using Hughes scale (0-6).
Results:
Demyelinating variety in 57 patients (52.8%) was more common than the axonal variety (33.3%). 71.1% (32/45) of GBS patients had recovered (scale 0,1) during the follow up period of 6 months. These included 67.7% (21/31) of the axonal variety and 78.6% (11/14) of the demyelinating variety.
Conclusions:
Irrespective of the severity, disability is less with the demyelinating variety as compared with the axonal subtype.
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