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Updated: Nov 19, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Direct C2-arylation of N-acyl pyrroles with aryl halides under palladium catalysis
Weiqiang Chen1, Hui-Jing Li2, Yun-Fei Cheng1
1Weihai Marine Organism & Medical Technology Research Institute, Harbin Institute of Technology, Weihai 264209, P.R. China. ycwu@iccas.ac.cn.
Abstract:
C2-arylation of N-acyl pyrroles with aryl halides is developed for the first time using Pd(PPh3)4 as a catalyst in combination with Ag2CO3 under air, which allowed the application of a good compatibility catalytic system. This protocol provides a straightforward method for the preparation of valuable arylated pyrroles in moderate to good yields under the standard conditions with good substrate tolerance. Interestingly, while N-benzoyl pyrroles reacted well, the use of substrates with a thiophene or furan ring indicated that the thiophene and furan rings are more reactive than pyrrole for the present catalytic system.
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