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Thrombocytosis during Stable State Predicts Mortality in Bronchiectasis.
Stefano Aliberti1,2, Giovanni Sotgiu3, Andrea Gramegna1,2
1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, UO Pneumologia, Milan, Italy.
Annals of the American Thoracic Society
|January 28, 2021
Summary
Thrombocytosis, or high platelet count, is linked to increased disease severity and worse outcomes in adults with bronchiectasis. This finding highlights platelets as a valuable biomarker for assessing bronchiectasis progression and patient prognosis.
Area of Science:
- Pulmonary Medicine
- Hematology
- Clinical Research
Background:
- Platelets are recognized inflammatory mediators in respiratory diseases.
- The specific role of platelets in bronchiectasis remains underexplored.
- Thrombocytosis may indicate underlying inflammation and disease severity.
Purpose of the Study:
- To investigate the association between thrombocytosis and bronchiectasis severity.
- To determine if thrombocytosis predicts worse clinical outcomes in patients with bronchiectasis.
- To evaluate platelets as a potential biomarker in bronchiectasis management.
Main Methods:
- A multicenter study enrolled 1,771 adult patients with bronchiectasis.
- Platelet counts were assessed during stable disease state.
- Logistic regression analysis was used to assess outcomes, adjusting for confounding variables.
Main Results:
- 7.7% of patients presented with thrombocytosis.
- Thrombocytosis was significantly associated with higher disease severity, poorer quality of life, and increased exacerbations and hospitalizations.
- Patients with thrombocytosis had significantly higher 3-year and 5-year all-cause mortality rates.
Conclusions:
- Thrombocytosis in stable bronchiectasis is a significant indicator of disease severity.
- Elevated platelet counts are associated with increased hospitalizations due to exacerbations and higher mortality.
- Platelets serve as a cost-effective and easily assessable biomarker for predicting outcomes in bronchiectasis.
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