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Updated: Nov 19, 2025

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Conformation-dependent charge transport through short peptides.

Davide Stefani1, Cunlan Guo, Luca Ornago

  • 1Kavli Institute of Nanoscience, Delft University of Technology, Delft, The Netherlands. h.s.j.vanderzant@tudelft.nl.

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Charge transport through single peptides was studied using Mechanically Controlled Break Junction (MCBJ). Different peptide lengths and compositions yield distinct conductance values, crucial for understanding charge transport in biomolecules.

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Area of Science:

  • Molecular electronics
  • Biophysics
  • Materials science

Background:

  • Understanding charge transport in biomolecules is essential for developing novel electronic devices.
  • Single-molecule junctions provide a platform to study fundamental charge transport mechanisms.

Purpose of the Study:

  • To investigate charge transport characteristics across single short peptides.
  • To correlate peptide conformation with conductance values.
  • To explore the influence of peptide length and composition on charge transport.

Main Methods:

  • Utilized the Mechanically Controlled Break Junction (MCBJ) technique to form single-molecule junctions.
  • Recorded thousands of electron transport events across individual peptide molecules.
  • Employed unsupervised machine learning algorithms to classify conductance traces.

Main Results:

  • Identified distinct classes of conductance traces corresponding to different peptide conformations.
  • Shorter, rigid peptides exhibited lower conductance plateaus (~10^-3 G0).
  • Longer, flexible peptides showed higher conductance plateaus.
  • Fully stretched peptides displayed conductance comparable to similar-length alkane chains.

Conclusions:

  • Peptide length and composition significantly influence charge transport properties.
  • Conformational flexibility plays a key role in determining conductance values.
  • These findings are critical for advancing the understanding of charge transport in peptide-based biomolecules.