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Published on: January 7, 2019
The role of post-translational modifications in the regulation of MCL1
Shujing Li1, Wanping Guo1, Huijian Wu1
1School of Bioengineering & Province Key Laboratory of Protein Modification and Disease, Liaoning Province, Dalian University of Technology, China.
Abstract:
Apoptosis is an evolutionarily conserved form of programed cell death (PCD) that has a vital effect on early embryonic development, tissue homeostasis and clearance of damaged cells. Dysregulation of apoptosis can lead to many diseases, such as Alzheimer's disease, cancer, AIDS and heart disease. The anti-apoptotic protein MCL1, a member of the BCL2 family, plays important roles in these physiological and pathological processes. Its high expression is closely related to drug resistances in the treatment of tumor. This review summarizes the structure and function of MCL1, the types of post-translational modifications of MCL1 and their effects on the functions of MCL1, as well as the treatment strategies targeting MCL1 in cancer therapy. The research on the fine regulation of MCL1 will be favorable to the provision of a promising future for the design and screening of MCL1 inhibitors.
Insights
MCL1, an anti-apoptotic protein, is crucial in cell death and disease. Understanding its regulation and targeting MCL1 offers promise for developing new cancer therapies.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- Apoptosis, or programmed cell death, is vital for development and tissue health.
- MCL1, an anti-apoptotic protein in the BCL2 family, influences physiological and pathological processes.
- Elevated MCL1 expression correlates with drug resistance in cancer treatment.
Purpose of the Study:
- To review the structure, function, and post-translational modifications of MCL1.
- To explore the impact of MCL1 modifications on its functions.
- To summarize current and future treatment strategies targeting MCL1 in cancer therapy.
Main Methods:
- Literature review of scientific publications on MCL1.
- Analysis of MCL1 structure and function.
- Examination of post-translational modifications of MCL1.
- Review of cancer treatment strategies targeting MCL1.
Main Results:
- MCL1 plays a significant role in apoptosis regulation.
- Post-translational modifications fine-tune MCL1's anti-apoptotic activity.
- Targeting MCL1 presents a promising avenue for cancer treatment.
Conclusions:
- Detailed understanding of MCL1 regulation is key for developing effective inhibitors.
- Targeting MCL1 holds potential for overcoming drug resistance in cancer therapy.
- Further research into MCL1 fine-tuning will advance cancer treatment strategies.
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