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TRIM21 - A potential novel therapeutic target in cancer

Munther Alomari1

  • 1Department of Stem Cell Biology, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Post Box No. 1982, Dammam 31441, Saudi Arabia.

Pharmacological Research
|January 28, 2021
PubMed

Insights

Tripartite motif-containing protein 21 (TRIM21) has a dual role in cancer, potentially promoting or suppressing tumor growth. Understanding TRIM21

Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • Tripartite motif-containing protein 21 (TRIM21) is implicated in innate immunity and autoimmune diseases.
  • TRIM21's role in cancer proliferation and suppression is not fully understood.
  • Its clinical significance in oncology remains elusive.

Purpose of the Study:

  • To elucidate the multifaceted role of TRIM21 in cancer.
  • To investigate TRIM21's impact on key cancer-promoting proteins.
  • To compare TRIM21 signaling pathways under normal and carcinogenic conditions.

Main Methods:

  • Analysis of TRIM21 effects on NF-κB, STAT3, BCL2, p53, p27, and Snail.
  • Comparison of TRIM21 signaling pathways under normal conditions.
  • Evaluation of TRIM21 activity in the presence of oncogenic, genotoxic, and UV irradiation stimuli.

Main Results:

  • TRIM21 exhibits context-dependent effects on cancer proliferation.
  • It can enhance cancer cell growth or promote apoptosis via ubiquitination.
  • TRIM21 influences major cancer-related signaling pathways.

Conclusions:

  • TRIM21 plays a significant, dual role in cancer proliferation and/or apoptosis.
  • Its function is modulated by cancer type and specific carcinogenic effectors.
  • TRIM21 represents a potential therapeutic target for cancer treatment.
Keywords:
Cancer proliferationCisplatin (CID: 5702198)GMPSHuRNF-κBProteasomal degradationTemozolomide (CID: 5394)p53

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