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Related Experiment Video

Updated: Nov 19, 2025

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Can S100B Predict and Evaluate Post-Traumatic Hydrocephalus.

Wanhong Zhang1, Henghao Wu1, Shengxu Zhang1

  • 1Department of Neurosurgery, Kaifeng Central Hospital, Kaifeng, China.

World Neurosurgery
|January 28, 2021
PubMed
Summary

Plasma S100B protein levels can predict post-traumatic hydrocephalus (PTH) in patients with traumatic brain injury. Elevated S100B levels correlate with increased intracranial pressure, aiding in early PTH detection.

Keywords:
Intracranial pressurePost-traumatic hydrocephalusS100B proteinSeverity of hydrocephalus

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Trauma Surgery

Background:

  • Post-traumatic hydrocephalus (PTH) is a frequent complication following craniocerebral injury.
  • Delayed diagnosis of PTH can lead to severe clinical deterioration and poor patient outcomes.
  • Early detection and treatment of PTH are crucial for successful management.

Purpose of the Study:

  • To evaluate plasma S100B protein as a potential biochemical marker for predicting PTH.
  • To investigate the correlation between S100B protein levels, intracranial pressure, and PTH severity.

Main Methods:

  • Retrospective analysis of 235 traumatic brain injury patients (June 2014 - June 2019).
  • Collection of three serum S100B samples per patient: early post-injury, post-treatment stable period, and upon PTH confirmation.
  • Measurement of intracranial pressure via lumbar puncture.

Main Results:

  • 46 out of 235 patients (19%) developed PTH.
  • No significant difference in S100B levels in early samples between patients with and without PTH.
  • Significantly higher S100B levels in the third sample for patients with PTH compared to those without.

Conclusions:

  • Serum S100B measurements show potential for predicting PTH development.
  • A positive correlation exists between S100B levels and intracranial pressure.
  • S100B levels did not correlate with the severity of PTH but are clinically significant for early detection.