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Primary mediastinal large B-cell lymphoma in a patient on Fingolimod for relapsing-remitting multiple sclerosis
Joseph A Chacko1, Paolo Strati2, Paul W Stout3
1College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Background:
There are multiple case reports in the literature describing an association between fingolimod and cutaneous neoplasms.
Objective:
Investigate and report a case of a primary mediastinal large B-cell lymphoma in a patient on fingolimod for Relapsing-Remitting Multiple Sclerosis (RRMS).
Methods:
Case Report.
Results:
The patient developed a primary mediastinal large B-cell lymphoma after seven years of treatment with fingolimod. The patient is currently in complete remission after cessation of treatment, surgical resection, chemotherapy, and radiation therapy.
Conclusion:
This case report highlights the first primary mediastinal large B-cell lymphoma associated with fingolimod treatment. It should be considered a rare, but potential adverse effect of fingolimod.
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