Related Experiment Video
Updated: Nov 19, 2025
Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics
Published on: October 2, 2014
A case of IVIg responsive paraneoplastic SOX1 peripheral neuropathy in a male with breast carcinoma
Reuben Beer1, Cullen O'Gorman2, Keith Horwood3
1Princess Alexandra Hospital, Woolloongabba, Queensland, Australia; University of Queensland, St Lucia, Queensland, Australia.
Background And Aims:
SOX1 antibodies are generally associated with small cell lung cancer and anti-Hu antibody overlap is common. This case demonstrates isolated anti-SOX1 antibodies with an uncommon tumor type, and relapse of a paraneoplastic syndrome with recurrence of tumor.
Methods:
We describe a case of a 65-year-old male with a paraneoplastic peripheral neuropathy and anti-SOX1 antibody positivity in the context of a prior male breast Grade 2 ductal carcinoma, in remission at the time of the initial neurological presentation.
Results:
Treatment response to intravenous immunoglobulin (IVIg) was demonstrated. After period of clinical stability on IVIg in the context of remission of breast carcinoma, the patient experienced a relapse of his neuropathy. This was associated with tumor recurrence and again responded to tumor excision, radiotherapy and IVIg.
Interpretation:
Male breast carcinoma has not previously been associated with anti-SOX1 antibody positive paraneoplastic neuropathy.
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