Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

1.1K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.1K
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

614
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
614
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

276
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
276
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

263
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
263
Bipolar Disorder01:30

Bipolar Disorder

308
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
308
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

334
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
334

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sexual function despite hyperprolactinemia: a 24-month analysis of paliperidone palmitate versus haloperidol decanoate.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2026
Same author

Neuroinflammation and Secretase Regulation in Alzheimer's Disease: From Molecular Cross-Talk to Multi-Target Therapeutics.

International journal of molecular sciences·2026
Same author

Phytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.

International journal of molecular sciences·2026
Same author

Beyond the Genomic Storm: Evaluating Tabernanthalog as a Potential Scaffold for Silent Neuroplasticity and Broad-Spectrum Therapy.

International journal of molecular sciences·2026
Same author

Immersive Technologies for Cognitive Rehabilitation in Dementia and Mild Cognitive Impairment: Systematic Review.

Journal of medical Internet research·2026
Same author

Neuropsychiatric and behavioural correlates of sundowning in Alzheimer's disease.

International journal of psychiatry in clinical practice·2026

Related Experiment Video

Updated: Nov 19, 2025

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

907

Possible Modulatory Role of ARC Gene Variants in Mood Disorders.

Concetta Crisafulli1, Marco Calabrò1, Laura Mandelli2

  • 1Department of Biomedical and Dental Sciences and Morphofunctional Images, University of Messina, Messina.

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology
|January 28, 2021
PubMed
Summary

Genetic variants in the ARC gene show potential links to mood disorder symptoms and traits. Further research is needed to confirm the role of ARC gene variations in major depressive disorder and bipolar disorder.

Keywords:
ARC geneBipolar disorderDepressive disorderMood disorder

More Related Videos

A High-content Assay for Monitoring AMPA Receptor Trafficking
10:34

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

7.8K
Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

791

Related Experiment Videos

Last Updated: Nov 19, 2025

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

907
A High-content Assay for Monitoring AMPA Receptor Trafficking
10:34

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

7.8K
Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

791

Area of Science:

  • Genetics
  • Psychiatry
  • Molecular Biology

Background:

  • Understanding the genetic underpinnings of mood disorders is crucial for developing targeted treatments.
  • Detailed phenotyping alongside genetic analysis can illuminate the function of modulating genetic variants.

Purpose of the Study:

  • To investigate the potential modulatory effects of ARC gene variants on mood disorder phenotypes.
  • To explore associations between specific ARC gene single nucleotide polymorphisms and clinical characteristics in European and Korean mood disorder cohorts.

Main Methods:

  • Analysis of ARC gene variants in two independent mood disorder samples: European (n=246 bipolar disorder) and Korean (n=132 bipolar disorder, n=242 major depressive disorder).
  • Phenotypic data included symptom severity (Hamilton Depression Rating Scale), family history, suicide risk, and body mass index.

Main Results:

  • While no results met Bonferroni correction, trends suggested associations between ARC gene variants and mood disorder phenotypes.
  • Weak correlations were observed between specific ARC SNPs (rs7465272, rs11167152) and depressive symptom severity in Korean and European MDD samples.
  • Other SNPs (rs10110456, rs7465272) showed associations with family history and suicide risk in the Korean sample, and rs7465272 with BMI in the European sample.

Conclusions:

  • ARC gene variants may play a partial role in modulating mood disorder phenotypes and potentially treatment efficacy.
  • Larger sample sizes are required to further elucidate the specific contributions of ARC gene variants to symptom severity and treatment outcomes in mood disorders.