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Poly(aspartic acid)-based pH-responsive targeting co-delivery nanoparticles.

Qiang Li1, Dongsheng Fu1, Jie Zhang1

  • 1College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, China.

Journal of Biomaterials Applications
|January 29, 2021
PubMed
Summary
This summary is machine-generated.

pH-responsive nanoparticles co-loaded with doxorubicin and curcumin show enhanced anticancer activity. The HA-EDA-PASP-Tyr (HEPT) nanocarrier effectively delivers dual agents, improving cancer treatment strategies.

Keywords:
Polypeptideco-deliverycurcumindoxorubicinhyaluronic acidpH-sensitivity

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Drug Delivery

Background:

  • Nanocarrier encapsulation enhances therapeutic molecule delivery for effective cancer treatment.
  • Dual-agent delivery systems offer synergistic therapeutic effects.
  • pH-responsive and actively targeted nanocarriers are crucial for precise cancer therapy.

Purpose of the Study:

  • To prepare pH-responsive, dual-agent loaded nanoparticles for enhanced cancer treatment.
  • To evaluate the physicochemical properties, drug loading, and anticancer efficacy of the novel nanocarrier.
  • To investigate the cellular uptake mechanism and targeting capability of the nanocarrier.

Main Methods:

  • Synthesis of hyaluronic acid-ethylenediamine-poly(aspartic acid)-tyrosine (HA-EDA-PASP-Tyr or HEPT) nanocarriers.
  • Encapsulation of doxorubicin hydrochloride (DOX) and curcumin (CUR) into HEPT nanoparticles.
  • Characterization of particle size, morphology, and pH-responsive behavior.
  • In vitro cytotoxicity assays and confocal laser scanning microscopy for cellular uptake studies.

Main Results:

  • HEPT nanoparticles exhibited high loading capacity for both DOX (26.0±1.9%) and CUR (50.9±4.3%).
  • Nanoparticles showed pH-responsive swelling and morphological changes in acidic conditions.
  • Co-loaded (DOX+CUR)@HEPT nanoparticles demonstrated significantly higher cytotoxicity against HCT-116 cells compared to free drugs.
  • Hyaluronic acid ligand facilitated enhanced cellular uptake via active targeting.

Conclusions:

  • The developed HEPT nanocarrier system effectively co-delivers DOX and CUR with high loading efficiency.
  • The pH-responsive and actively targeted nanoparticles exhibit superior in vitro anticancer efficacy.
  • This dual-drug delivery system presents a promising strategy for advanced cancer therapy.