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Stereotactic radiosurgery for treating meningiomas eligible for complete resection
Maximilian I Ruge1, Juman Tutunji2, Daniel Rueß2
1Department of Stereotactic and Functional Neurosurgery, Centre for Neurosurgery, Medical Faculty of the University of Cologne, Kerpener Strasse 62, LFI Gebäude Ebene 2, 50937, Cologne, Germany. Maximimilian.ruge@uk-koeln.de.
Radiation Oncology (London, England)
|January 29, 2021
Summary
Stereotactic radiosurgery (SRS) offers effective, long-term local control for meningiomas in patients ineligible for surgery. This treatment demonstrates a low rate of mild side effects, making it a viable option for select cases.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Complete surgical resection is the primary treatment for meningiomas.
- Stereotactic radiosurgery (SRS) is an alternative for smaller or inoperable meningiomas.
- SRS is also considered when surgery is contraindicated due to patient condition or preference.
Purpose of the Study:
- To evaluate the efficacy and safety of SRS for meningiomas in patients eligible for complete resection.
- To assess local and regional tumor control rates following SRS.
- To determine treatment-related adverse events associated with SRS.
Main Methods:
- Retrospective single-center analysis of patients with intracranial meningiomas treated with single-fraction SRS.
- Utilized modified LINAC or robotic CyberKnife guidance.
- Follow-up imaging and Kaplan-Meier method were used to assess outcomes and adverse events.
Main Results:
- 188 patients with 218 meningiomas were analyzed, with median follow-up exceeding 50 months.
- Excellent local control with only one recurrence (0.5%) at 239 months.
- Low regional recurrence rates (15-year rate of 6.6%) and manageable adverse events (11.2% early, 14.4% late).
Conclusions:
- SRS is an effective treatment for meningiomas in patients suitable for resection.
- Provides reliable long-term local tumor control.
- Associated with low rates of mild morbidity, supporting its use in select meningioma cases.
Keywords:
Adverse eventsLocal controlMeningioma WHO grade IRegional controlStereotactic radiosurgery (SRS)
