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Abstract:
Spontaneous multiple jejunal perforations developed in a relatively normal patient. Candida albicans was cultured from a biopsy specimen of an area of perforation and from peritoneal fluid. Yeasts and pseudohyphae were seen deep within the necrotic mucosa. Serial determinations of precipitating and agglutinating antibodies support the diagnosis of invasive candidiasis causing this unusual presentation.
Insights
Invasive candidiasis caused spontaneous jejunal perforations in a patient. Antibody evidence confirmed the fungal infection, highlighting a rare presentation of Candida albicans.
Area of Science:
- Gastroenterology
- Mycology
- Infectious Diseases
Background:
- Spontaneous gastrointestinal perforations are rare, especially in otherwise healthy individuals.
- Invasive fungal infections, particularly candidiasis, can present with diverse and severe manifestations.
Observation:
- Multiple jejunal perforations were observed in a patient with no significant prior medical history.
- Microscopic examination revealed Candida albicans yeasts and pseudohyphae within the necrotic mucosal tissue.
- Fungal elements were also identified in peritoneal fluid samples.
Findings:
- Culture of Candida albicans from perforation biopsy and peritoneal fluid confirmed fungal presence.
- Serological testing showed precipitating and agglutinating antibodies against Candida, supporting an invasive infection.
- The findings indicate invasive candidiasis as the etiology of the jejunal perforations.
Implications:
- This case highlights an unusual and severe presentation of invasive candidiasis.
- It underscores the importance of considering fungal infections in unexplained gastrointestinal perforations.
- Early diagnosis and treatment of invasive candidiasis are crucial for patient outcomes.