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Complete Genome Sequence of Klebsiella pneumoniae Jumbo Phage Miami
Daniel Mora1, Lauren Lessor1, Tram Le1
1Center for Phage Technology, Texas A&M University, College Station, Texas, USA.
Microbiology Resource Announcements
|January 29, 2021
Abstract:
Bacteriophage Miami infects Klebsiella pneumoniae, a Gram-negative pathogen that is becoming an increasing threat to public health due to its multidrug resistance. Here, we describe the annotation of the 253,383-bp jumbo phage Miami genome sequence and its similarity to other myophages.
Insights
Researchers annotated the genome of Bacteriophage Miami, which targets the multidrug-resistant bacterium Klebsiella pneumoniae. This study details the phage
Area of Science:
- Microbiology
- Genomics
- Virology
Background:
- Klebsiella pneumoniae is a multidrug-resistant pathogen posing a significant public health risk.
- Bacteriophages offer potential alternatives for combating antibiotic-resistant bacteria.
Purpose of the Study:
- To annotate the genome sequence of Bacteriophage Miami.
- To analyze the genomic similarity of Bacteriophage Miami to other myophages.
Main Methods:
- Genome sequencing of Bacteriophage Miami.
- Bioinformatic analysis for genome annotation.
- Comparative genomic analysis with related myophages.
Main Results:
- The complete genome sequence of Bacteriophage Miami was annotated.
- The genome size was determined to be 253,383 base pairs.
- Genomic comparisons revealed similarities to other myophages.
Conclusions:
- The genomic characterization of Bacteriophage Miami provides insights into its biology.
- Understanding phage-host interactions can aid in developing phage-based therapies against Klebsiella pneumoniae.
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