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Morphological variables associated with ruptured basilar tip aneurysms.

Jian Zhang^1,2, Anil Can^1,3, Pui Man Rosalind Lai¹

¹Department of Neurosurgery, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.

Scientific Reports

|January 29, 2021

Summary

This summary is machine-generated.

Morphological features like daughter domes and aspect ratio are linked to ruptured basilar tip aneurysms. New parameters, diameter size ratio and parent-daughter angle ratio, may help identify rupture risk in patients with these intracranial aneurysms.

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Published on: July 28, 2018

Area of Science:

Neurosurgery
Radiology
Medical Imaging

Background:

Intracranial aneurysms, particularly at the basilar tip, pose a significant rupture risk.
Morphological characteristics of aneurysms and adjacent vasculature can influence rupture likelihood.
Location-specific factors are crucial in assessing aneurysm rupture potential.

Purpose of the Study:

To identify image-based morphological parameters correlating with ruptured basilar tip aneurysms.
To evaluate the association between specific aneurysm and vessel dimensions and rupture status.
To introduce and validate novel morphological parameters for rupture risk assessment.

Main Methods:

Analysis of 3D morphological parameters from CT-angiography (CTA) or digital subtraction angiography (DSA) in 200 patients.
Evaluation of parameters including aneurysm wall irregularity, daughter domes, PCoA variations, vertebral dominance, and various dimensional ratios.
Application of univariable and multivariable statistical analyses to determine significance.

Main Results:

Presence of a daughter dome, aspect ratio, and larger flow angle were significantly associated with rupture.
New parameters, diameter size ratio and parent-daughter angle ratio, showed inverse association with rupture.
Larger diameter size ratio correlated with higher Hunt-Hess score; smaller flow angle with higher Fisher grade.

Conclusions:

Easily measurable morphological parameters, including novel ones, can aid in screening high-risk patients with basilar tip aneurysms.
These parameters may improve the identification of ruptured intracranial aneurysms.
Potential secondary changes due to rupture should be considered when interpreting morphological parameters.