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Updated: Nov 19, 2025

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
Cost saving analysis of specialized, eHealth-based management of patients receiving oral anticoagulation therapy:
Lisa Eggebrecht1,2, Paul Ludolph1,3, Sebastian Göbel4,5
1Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstraße 1, Mainz, 55131, Germany.
Insights
A specialized eHealth management service significantly reduced hospitalizations for oral anticoagulation therapy patients. This resulted in substantial cost savings of 2368 EUR per patient annually compared to regular medical care.
Area of Science:
- Health Economics
- Digital Health
- Pharmacology
Background:
- Oral anticoagulation (OAC) therapy requires careful management to prevent adverse events.
- Regular medical care (RMC) for OAC patients can incur significant healthcare costs.
- eHealth-based specialized care services offer potential for improved patient outcomes and cost-efficiency.
Purpose of the Study:
- To compare the cost-effectiveness of a specialized eHealth-based management service (CS) versus RMC for OAC patients.
- To evaluate hospitalization rates and associated costs in both management approaches.
Main Methods:
- A comparative study involving 705 patients in the CS cohort and 1490 in the RMC cohort.
- Hospitalization costs were calculated using diagnosis-related groups (ICD-10, OPS).
- Costs included OAC-related events (bleeding, thromboembolism) and general management expenses (INR testing, personnel).
Main Results:
- Hospitalization rates were significantly lower in the CS cohort (23.4/100 py) compared to RMC (68.7/100 py).
- OAC-related admissions were markedly reduced in the CS group (2.8/100 py) versus RMC (13.3/100 py).
- Overall cost savings favored the CS, with 2368 EUR/py saved, driven by reduced hospitalization expenses.
Conclusions:
- The specialized eHealth management service for OAC patients leads to substantial cost savings.
- Reduced adverse events and hospitalizations are key drivers of cost-efficiency in telemedicine-based OAC management.
- Implementing specialized eHealth services can optimize resource allocation in anticoagulation care.
Abstract:
To evaluate the cost-saving of a specialized, eHealth-based management service (CS) in comparison to regular medical care (RMC) for the management of patients receiving oral anticoagulation (OAC) therapy. Costs of hospitalization were derived via diagnosis-related groups which comprise diagnoses (ICD-10) and operation and procedure classification system (OPS), which resulted in OAC-related (i.e. bleeding/ thromboembolic events) and non-OAC-related costs for both cohorts. Cost for anticoagulation management comprised INR-testing, personnel, and technical support. In total, 705 patients were managed by CS and 1490 patients received RMC. The number of hospital stays was significantly lower in the CS cohort compared to RMC (CS: 23.4/100 py; RMC: 68.7/100 py); with the most pronounced difference in OAC-related admissions (CS: 2.8/100 py; RMC: 13.3/100 py). Total costs for anticoagulation management amounted to 101 EUR/py in RMC and 311 EUR/py in CS, whereas hospitalization costs were 3261 [IQR 2857-3689] EUR/py in RMC and 683 [504-874] EUR/py in CS. This resulted in an overall cost saving 2368 EUR/py favoring the CS. The lower frequency of adverse events in anticoagulated patients managed by the telemedicine-based CS compared to RMC translated into a substantial cost-saving, despite higher costs for the specialized management of patients.Trial registration: ClinicalTrials.gov, unique identifier NCT01809015, March 8, 2013.
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