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Related Experiment Videos

Quantitative flow measurement in phase contrast MR angiography.

M F Walker1, S P Souza, C L Dumoulin

  • 1General Electric Corporate Research and Development Center, Schenectady, NY 12301.

Journal of Computer Assisted Tomography
|March 1, 1988
PubMed
Summary

This study presents a new method for accurate blood flow measurement using phase contrast magnetic resonance angiography. This technique is independent of system and patient variations, enabling reliable quantitative flow data.

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Area of Science:

  • Medical Imaging
  • Cardiovascular Physiology
  • Biomedical Engineering

Background:

  • Phase contrast magnetic resonance angiography (PC-MRA) is crucial for visualizing blood flow.
  • Accurate quantitative flow measurement in PC-MRA can be challenging due to system and patient variability.
  • Existing methods may require complex calibration or be sensitive to physiological changes.

Purpose of the Study:

  • To explore the quantitative nature of PC-MRA.
  • To present a novel blood flow measurement technique independent of system and patient parameters.
  • To demonstrate the accuracy and routine applicability of this calibration method.

Main Methods:

  • Developed a calibration technique for PC-MRA requiring only two flow image acquisitions.

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  • Validated the method using phantom and patient studies.
  • Accounted for factors like nonuniform sensitivity profiles, blood flow pulsatility, and system gain variations.

    • Main Results:

    • Quantitative flow measurements using PC-MRA were obtained with good accuracy.
    • The technique proved robust despite variations in sensitivity profiles, flow pulsatility, and system gain.
    • The calibration method is efficient, requiring minimal acquisition time within an angiographic session.

    Conclusions:

    • The presented calibration technique enables routine, accurate, and robust quantitative blood flow measurement with PC-MRA.
    • This method overcomes common limitations, enhancing the clinical utility of PC-MRA for flow assessment.
    • The technique is versatile, applicable to any flow profile, including plug and parabolic flow.