Merkel cell tumor of the thigh

Area of Science:

• Oncology
• Dermatopathology
• Surgical Pathology

Background:

• Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer.
• Most MCCs occur on sun-exposed areas like the head and neck.
• This report presents an atypical case of MCC on the thigh.

Observation:

• Histological examination revealed sheets of uniform, poorly differentiated cells.
• Cells exhibited a high nuclear-to-cytoplasmic ratio.
• Electron microscopy identified characteristic perinuclear filaments and dense core granules.

Findings:

• The tumor presented as a nodule on the thigh, deviating from the typical head and neck presentation.
• Microscopic analysis confirmed the diagnosis of Merkel cell carcinoma.
• Ultrastructural features were consistent with MCC.

Implications:

• Highlights the importance of considering MCC in unusual locations.
• Emphasizes the role of histopathology and electron microscopy in diagnosing challenging cases.
• Surgical excision with wide margins remains a primary treatment modality for localized MCC.