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Prolonged Systemic Inflammation Alters Muscarinic Long-Term Potentiation (mLTP) in the Hippocampus

Efrat Shavit-Stein1,2, Amir Dori1,2, Marina Ben Shimon1,2

  • 1Department of Neurology, The Chaim Sheba Medical Center, Ramat Gan, 52621 Tel HaShomer, Israel.

Neural Plasticity
|January 29, 2021
PubMed

Insights

Systemic inflammation impacts muscarinic long-term potentiation (mLTP), crucial for learning and memory. Acute inflammation causes temporary deficits, while persistent inflammation leads to lasting impairments in mLTP.

Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Cognitive Function

Background:

  • The cholinergic system, particularly muscarinic M1 receptors (M1R), is vital for learning and memory via muscarinic long-term potentiation (mLTP).
  • Cognitive impairment and dementia are linked to cholinergic dysfunction and neuroinflammation.
  • Systemic inflammation's effect on mLTP remains understudied.

Purpose of the Study:

  • To investigate how acute versus persistent systemic inflammation affects hippocampal mLTP.
  • To explore the relationship between systemic inflammation and cholinergic-mediated synaptic plasticity.

Main Methods:

  • Induction of acute and persistent systemic inflammation using lipopolysaccharide (LPS) injections in a rodent model.
  • Assessment of hippocampal synaptic transmission and the ability to induce mLTP.

Main Results:

  • Acute LPS exposure induced a transient deficit in mLTP expression.
  • Persistent LPS exposure resulted in a persistent impairment of mLTP.
  • Differential effects of inflammation duration on synaptic plasticity were observed.

Conclusions:

  • Systemic inflammation, particularly when persistent, significantly impairs mLTP.
  • These findings suggest a mechanism linking inflammation-induced cognitive deficits to impaired cholinergic synaptic function.
  • The study highlights the potential role of neuroinflammation in cognitive dysfunction following conditions like sepsis.

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