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Related Concept Videos

Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

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The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
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Embryonic Stem Cells00:58

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Cleavage and Blastulation01:33

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After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
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Maintenance of the ES Cell State01:14

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The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
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The Production of Pluripotent Stem Cells from Mouse Amniotic Fluid Cells Using a Transposon System
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BAF Complex in Embryonic Stem Cells and Early Embryonic Development.

Heyao Zhang1, Xuepeng Wang2, Jingsheng Li1

  • 1Cam-Su Genomic Resource Center, Medical College of Soochow University, Suzhou, Jiangsu 215000, China.

Stem Cells International
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Summary
This summary is machine-generated.

Embryonic stem cells (ESCs) self-renew and maintain pluripotency via gene networks and chromatin remodelers. This review details the BAF complex

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Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Epigenetics

Background:

  • Embryonic stem cells (ESCs) possess indefinite self-renewal and pluripotency.
  • Gene regulatory networks and chromatin remodeling complexes are crucial for maintaining ESC properties.
  • The BAF complex is a key chromatin remodeler involved in embryonic development.

Purpose of the Study:

  • To review research on the function and mechanisms of the BAF complex in mouse ESCs.
  • To explore the BAF complex's role in early embryonic development.
  • To discuss how deleting different BAF subunits affects ESCs and embryos.

Main Methods:

  • Literature review of functional and mechanistic studies.
  • Analysis of phenotypes resulting from BAF subunit deletion.
  • Focus on mouse ESCs and early embryonic development.

Main Results:

  • The BAF complex plays a critical role in ESC self-renewal and pluripotency.
  • Specific BAF subunits have distinct functions in ESCs and embryonic development.
  • Understanding BAF complex mechanisms provides insight into developmental processes.

Conclusions:

  • The BAF complex is essential for maintaining pluripotency and regulating gene expression in ESCs.
  • Distinct BAF subunits contribute uniquely to embryonic development.
  • Further research into BAF complex mechanisms will illuminate stem cell biology and developmental processes.