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Improving Personalized Structure to Function Mapping From Optic Nerve Head to Visual Field.

Andrew Turpin1, Allison M McKendrick2

  • 1School of Computing & Information Systems, The University of Melbourne, Melbourne, Australia.

Translational Vision Science & Technology
|January 29, 2021
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Summary
This summary is machine-generated.

Individualized structure-to-function mapping (CUSTOM-MAP) shows higher concordance with glaucomatous visual field loss than population-based maps (POP-MAP). This personalized approach improves the relationship between optic nerve head structure and visual function.

Keywords:
glaucomamappingoptical coherence tomographyperimetrystructure-functionvisual field

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Neuroscience

Background:

  • Accurate mapping of visual field defects to optic nerve head (ONH) regions is crucial for understanding glaucoma progression.
  • Current population-derived maps (POP-MAP) may not fully capture individual variations in structure-function relationships.

Purpose of the Study:

  • To compare the concordance of individualized structure-to-function mapping (CUSTOM-MAP) with a population-derived mapping schema (POP-MAP).
  • To assess the effectiveness of personalized mapping in relating visual field locations to ONH regions in glaucoma patients.

Main Methods:

  • Compared CUSTOM-MAP and POP-MAP in 118 eyes with glaucomatous field loss.
  • Utilized spectral domain optical coherence tomography (OCT) for circumpapillary retinal nerve fiber layer (cpRNFL) thickness measurements.
  • Mapped visual field damage locations to ONH sectors and determined concordance ratios based on cpRNFL damage probability levels.

Main Results:

  • CUSTOM-MAP demonstrated a higher mean concordance ratio than POP-MAP under the strictest criteria (60.5% vs. 57.0%, P = 0.005).
  • CUSTOM-MAP showed improved concordance for more eyes and across various cpRNFL probability levels (<20% of normal).
  • Spatial analysis indicated CUSTOM-MAP performed better in arcuate regions, while POP-MAP was more beneficial inferior to the macula.

Conclusions:

  • Individualized structure-function mapping, using readily available OCT parameters, can enhance concordance between structural and functional measures in glaucoma.
  • Personalizing these maps offers potential for improved diagnostic accuracy and patient management.