Related Experiment Video
Updated: Nov 19, 2025
09:19
Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
Published on: December 8, 2017
15.2K
Neuronal guidance proteins in cardiovascular inflammation
Marius Keller1, Valbona Mirakaj2, Michael Koeppen2
1Department of Anesthesiology and Intensive Care Medicine, University Hospital Tübingen, Eberhard-Karls-University, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany. marius.keller@med.uni-tuebingen.de.
Basic Research in Cardiology
|January 29, 2021
Summary
Inflammation drives cardiovascular diseases. Neuronal guidance proteins (NGPs) are emerging as key regulators of inflammation and immune cell activation, offering potential new therapeutic targets for cardiovascular inflammation.
Area of Science:
- Cardiovascular biology and immunology
- Neuroscience and inflammation
Background:
- Cardiovascular pathologies are frequently initiated by inflammation.
- Inflammatory responses impact vascular endothelium, ischemia-reperfusion injury, immune cell migration, and platelet activation.
- Traditional therapeutic strategies targeting cytokines and chemokines have yielded variable success.
Purpose of the Study:
- To review the role of neuronal guidance proteins (NGPs) in cardiovascular inflammation.
- To highlight NGPs as potential therapeutic targets for managing cardiovascular inflammation.
Main Methods:
- Literature review focusing on the intersection of NGPs, inflammation, and cardiovascular disease.
- Analysis of current understanding of NGP involvement in immune cell regulation and tissue inflammation.
Main Results:
- Neuronal guidance proteins (NGPs) play a significant role in controlling tissue inflammation.
- NGPs are involved in immune cell activation mechanisms.
- These proteins represent a novel class of molecules implicated in cardiovascular inflammatory processes.
Conclusions:
- Neuronal guidance proteins (NGPs) are critically involved in regulating inflammation within the cardiovascular system.
- Targeting NGPs presents a promising future therapeutic avenue for controlling cardiovascular inflammation and its associated pathologies.
More Related Videos
Related Concept Videos
01:30Inflammatory Response I: Vascular and Cellular
14.3K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
14.3K
01:24Regulation of Angiogenesis and Blood Supply
3.0K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.0K
01:38Inflammation
57.8K
Overview
57.8K
01:27Psychoneuroimmunology: Cardiovascular Disease
181
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
181
01:27Regulation of the Cardiovascular System
2.9K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
2.9K
01:21Chemotaxis and Direction of Cell Migration
4.1K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
4.1K