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Related Experiment Video

Updated: Nov 19, 2025

Rapid Generation of Amyloid from Native Proteins In vitro

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

[Primary generalized AL amyloidosis].

E A Kogan¹, B B Saltykov¹, P V Atanov¹

¹I.M. Sechenov First Moscow State University (Sechenov University) of the Ministry of Health of Russia, Moscow, Russia.

Arkhiv Patologii

|January 29, 2021

Summary

This autopsy case study details a 71-year-old male with primary generalized AL amyloidosis. The condition progressed rapidly over four months, leading to fatal hepatic and renal failure.

Keywords:

morphology primary generalized AL amyloidosis

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Area of Science:

Pathology
Internal Medicine
Nephrology

Background:

Primary generalized AL amyloidosis is a rare plasma cell disorder.
It involves the deposition of misfolded immunoglobulin light chains, leading to organ dysfunction.
Rapid progression to multi-organ failure can occur.

Observation:

The study presents an autopsy of a 71-year-old male patient.
The patient had a history of primary generalized AL amyloidosis diagnosed approximately four months prior to death.
Death was attributed to hepatic and renal failure.

Findings:

Autopsy revealed significant damage to the liver and spleen.
Amyloid deposits were identified in the kidneys, adrenal glands, and pancreas.
These findings correlate with the observed hepatic and renal failure.

Implications:

This case highlights the aggressive nature and rapid progression of primary generalized AL amyloidosis.
It underscores the importance of early diagnosis and management to prevent severe organ damage.
Autopsy findings provide critical insights into the systemic impact of AL amyloidosis.