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Updated: Nov 19, 2025

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Mammalian VPS45 orchestrates trafficking through the endosomal system

Laura Frey1, Natalia Ziętara1, Marcin Łyszkiewicz1

  • 1Department of Pediatrics, Dr von Hauner Children's Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.

Blood
|January 29, 2021
PubMed
Summary

Vacuolar protein sorting 45 homolog (VPS45) is crucial for endosomal trafficking and receptor recycling. Its absence disrupts cellular organization, leading to developmental defects and impaired immune cell function.

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