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Fat tissue as an embolic material changes the embolization time in a size-dependent manner: a basic investigation
Kai Takaki1, Norihisa Nitta2, Shinichi Ota3
1Department of Radiology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan. ktakaki@belle.shiga-med.ac.jp.
Japanese Journal of Radiology
|January 29, 2021
Summary
Fat tissue can be used as an embolic material. The time it takes for embolization to occur depends on the size of the fat tissue used, impacting renal artery reperfusion rates.
Area of Science:
- Biomedical Engineering
- Vascular Surgery
- Regenerative Medicine
Background:
- Autologous fat grafting is a common procedure.
- Fat tissue's potential as an embolic material for vascular occlusion is under investigation.
- Understanding embolization characteristics is crucial for clinical application.
Purpose of the Study:
- To assess the efficacy of fat tissue as an embolic agent.
- To determine if fat tissue embolization time is influenced by its size.
- To evaluate the impact of fat tissue particle size on renal artery reperfusion.
Main Methods:
- Rabbit inguinal fat tissue was processed into 2-mm squares or dissociated into smaller particles (1-139 μm).
- Renal arteries were embolized with either fat tissue type.
- Renal angiography was performed at 1 and 7 days post-embolization to assess reperfusion rates.
Main Results:
- Embolization with larger fat tissue particles (2-mm squares) resulted in significantly lower reperfusion rates (4.0% at day 1, 29.9% at day 7) compared to smaller, dissociated particles (59.9% at day 1, 74.3% at day 7).
- A clear size-dependent difference in embolization efficacy was observed.
- Fat tissue particle size significantly influenced renal artery reperfusion.
Conclusions:
- Fat tissue is a viable embolic material for vascular occlusion.
- The embolization time and efficacy of fat tissue are dependent on its size.
- Tailoring fat tissue particle size can modulate embolization outcomes.
