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Rotavirus Gastroenteritis in Western Uttar Pradesh, India

Vipin M Vashishtha1, Nayana P Nair2, Mobeen Ahmad3

  • 1Department of Pediatrics, Mangla Hospital & Research Center, Shakti Chowk, Bijnor, Uttar Pradesh, 246701, India. vipinipsita@gmail.com.

Indian Journal of Pediatrics
|January 29, 2021
PubMed

Insights

Rotavirus (RV) causes significant acute gastroenteritis (AGE) in children under five in Uttar Pradesh, India. G1P[8] was the most common genotype, highlighting the need for surveillance and vaccine assessment.

Area of Science:

  • Virology
  • Public Health
  • Pediatrics

Background:

  • Rotavirus (RV) is a leading cause of severe acute gastroenteritis (AGE) in infants and young children globally.
  • Hospital-based surveillance is crucial for understanding the burden and epidemiology of RV infections.

Purpose of the Study:

  • To establish hospital-based surveillance for rotavirus (RV) in children under 5 years hospitalized with acute gastroenteritis (AGE).
  • To determine the burden and characterize circulating RV genotypes in western Uttar Pradesh, India.

Main Methods:

  • A prospective study was conducted from January 2018 to January 2020 at a tertiary hospital in Bijnor district.
  • Stool specimens from 932 children with AGE were tested for rotavirus. Data and specimens were transported via cold chain for analysis.

Main Results:

  • Rotavirus was detected in 39.5% of hospitalized children with AGE.
  • The highest incidence of RV-positive cases occurred during winter months, with the 0-11 month age group most affected.
  • G1 was the most frequent G-type (42.08%), and G1P[8] (26.23%) was the predominant circulating genotype.

Conclusions:

  • This study confirms a substantial burden of rotavirus (RV) in young children with AGE in western Uttar Pradesh.
  • Findings provide essential baseline data for the Indian government to evaluate rotavirus vaccine effectiveness post-introduction.
Abstract

Keywords:
Acute gastroenteritisGenotypeHospital-based surveillanceRotavirus

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