Related Experiment Video

Updated: Nov 19, 2025

Expression, Detergent Solubilization, and Purification of a Membrane Transporter, the MexB Multidrug Resistance Protein
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Expression, Detergent Solubilization, and Purification of a Membrane Transporter, the MexB Multidrug Resistance Protein

Published on: December 3, 2010

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Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance

Jing-Quan Wang1, Yuqi Yang1, Chao-Yun Cai1

  • 1Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
|January 29, 2021
PubMed

Insights

Multidrug resistance proteins (MRPs) are key in cancer drug resistance by extruding chemotherapy. Novel MRP modulators show promise in overcoming this resistance, offering new therapeutic avenues.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • ATP-binding cassette (ABC) transporters facilitate ATP-driven substrate translocation.
  • The ABCC subfamily, particularly multidrug resistance proteins (MRPs 1-9), plays a crucial role in cancer multidrug resistance (MDR).
  • MRPs also efflux vital organic anions, impacting regulatory pathways.

Purpose of the Study:

  • To review the structure, distribution, functions, and clinical relevance of MRPs.
  • To discuss recent advancements in MRP modulators and their therapeutic applications.
  • To highlight the potential of targeting MRPs for overcoming cancer MDR.

Main Methods:

  • Literature review of scientific publications on MRPs.
  • Analysis of data on MRP structure, tissue distribution, and biological functions.
  • Synthesis of information on pharmacological properties and clinical trial outcomes of MRP modulators.

Main Results:

  • MRPs are implicated in both cancer MDR and the transport of essential organic anions.
  • Inhibiting MRPs' drug efflux function is a viable strategy against cancer MDR.
  • Numerous novel MRP modulators have been developed and are under investigation.

Conclusions:

  • MRPs are critical targets for cancer therapy due to their role in MDR.
  • Targeting MRPs with novel modulators offers a promising approach to improve chemotherapy efficacy.
  • Further research and clinical trials are essential to fully realize the therapeutic potential of MRP modulators.
Keywords:
ABC transporterCancer chemotherapyMRPMultidrug resistance protein

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