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[Testosterone deficiency in the ageing male].

Nikolai Pirmin Jaschke1, Tilman D Rachner1, Lorenz C Hofbauer1

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Summary

Testosterone replacement therapy offers benefits for aging men, including improved sexual function and muscle mass. However, its long-term effects on cardiovascular disease and prostate cancer risk require further investigation through ongoing clinical trials.

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Area of Science:

  • Endocrinology
  • Geriatrics
  • Men's Health

Background:

  • Increasing demand for testosterone replacement therapy (TRT) in aging men across the US and Europe.
  • Existing evidence on low testosterone's adverse effects in older men primarily stems from retrospective studies.
  • Limited prospective, placebo-controlled randomized trials exist for clinically relevant endpoints in this population.

Purpose of the Study:

  • To review the clinical benefits of TRT in aging men.
  • To assess the current understanding of TRT's impact on cardiovascular disease and prostate cancer risk.
  • To highlight the need for ongoing research, such as the TRAVERSE trial, to clarify these risks.

Main Methods:

  • Review of existing literature, including retrospective studies and prospective trials.
  • Analysis of reported clinical benefits of TRT.
  • Identification of knowledge gaps regarding TRT's long-term safety outcomes.

Main Results:

  • TRT in aging men is associated with improved sexual function, libido, muscle mass and function, and bone accrual.
  • The impact of TRT on cardiovascular disease and prostate cancer risk remains uncertain.
  • Prospective randomized trials are crucial for definitive answers.

Conclusions:

  • TRT offers tangible benefits for aging men's health.
  • Further research is essential to determine the safety profile of TRT concerning cardiovascular and prostate health.
  • Ongoing trials are expected to provide critical data on TRT's long-term risks and benefits.