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Long Non-Coding RNA FENDRR: Gene Structure, Expression, and Biological Relevance
Przemyslaw Szafranski1, Paweł Stankiewicz1
1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Genes
|January 30, 2021
Summary
The FOXF1 Adjacent Noncoding Developmental Regulatory RNA (Fendrr) is crucial for mammalian development and gene regulation. Its deregulation is linked to diseases like cancer and fibrosis.
Area of Science:
- Molecular Biology
- Developmental Biology
- Genetics
Background:
- The FENDRR noncoding RNA is transcribed oppositely to the FOXF1 gene, sharing regulatory regions.
- FENDRR is located on human chromosome 16q24.1 and is regulated by cis-acting enhancers and trans-acting FOXF1.
- FENDRR acts as a competing endogenous RNA and an epigenetic modifier.
Purpose of the Study:
- To review the current understanding of FENDRR.
- To explore FENDRR's structure, expression, and role in development and tissue maintenance.
Main Methods:
- Literature review of FENDRR research.
- Analysis of FENDRR's regulatory mechanisms and functional roles.
Main Results:
- FENDRR is essential for heart, lung, and gastrointestinal development in mice, with homozygous loss causing lethality.
- FENDRR deregulation is implicated in tumorigenesis, chemotherapy resistance, fibrosis, and inflammatory diseases.
Conclusions:
- FENDRR is a key regulator in mammalian development and tissue homeostasis.
- Dysregulation of FENDRR has significant implications for various pathological conditions.
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