Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Surface Membrane Barriers

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...

Bacterial Phylum Actinobacteria

Bacterial Phylum Actinobacteria

Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...

Mechanism of Ciliary Motion

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Association between subjective symptoms and severity in patients with Fuchs endothelial corneal dystrophy.

Japanese journal of ophthalmology·2026

Same author

Crosstalk mediators implicated in the Stevens-Johnson Syndrome through gene regulatory network analysis.

BMC medical genomics·2026

Same author

Successful Cultivation of Oral Mucosal Epithelial Sheet Following Antifungal Therapy in Cases With Limbal Stem Cell Deficiency.

Cornea·2026

Same author

Intraocular Distribution and Aqueous-Vitreous Correlation of TGF-β Isoforms and GDF-15 in Retinal Diseases.

Current eye research·2026

Same author

Clinical performance of the multiplex solid-phase "Direct Strip PCR" for infectious uveitis: a multicenter diagnostic accuracy study.

Japanese journal of ophthalmology·2026

Same author

Peptide gel, CK2-085, maintains operative field visibility during surgery.

Scientific reports·2026

Search research articles

Related Experiment Video

Updated: Nov 19, 2025

Conjunctival Commensal Isolation and Identification in Mice

Conjunctival Commensal Isolation and Identification in Mice

Published on: May 1, 2021

Current Evidence for Corynebacterium on the Ocular Surface.

Takanori Aoki¹, Koji Kitazawa¹, Hideto Deguchi¹

¹Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan.

|January 30, 2021

Summary

Corynebacterium bacteria, often harmless on the eye, can cause infections in immunocompromised patients. Third-generation cephems are effective against these ocular infections, showing consistent susceptibility.

Keywords:

C. macginleyi C. mastitidis C. propinquum Corynebacterium conjunctivitis fluoroquinolone infectious keratitis resistant bacteria

More Related Videos

Impression Cytology of the Lid Wiper Area

Impression Cytology of the Lid Wiper Area

Published on: August 9, 2016

Isolation of Intact Eyeball to Obtain Integral Ocular Surface Tissue for Histological Examination and Immunohistochemistry

Isolation of Intact Eyeball to Obtain Integral Ocular Surface Tissue for Histological Examination and Immunohistochemistry

Published on: October 20, 2019

Related Experiment Videos

Last Updated: Nov 19, 2025

Conjunctival Commensal Isolation and Identification in Mice

Conjunctival Commensal Isolation and Identification in Mice

Published on: May 1, 2021

Impression Cytology of the Lid Wiper Area

Impression Cytology of the Lid Wiper Area

Published on: August 9, 2016

Isolation of Intact Eyeball to Obtain Integral Ocular Surface Tissue for Histological Examination and Immunohistochemistry

Isolation of Intact Eyeball to Obtain Integral Ocular Surface Tissue for Histological Examination and Immunohistochemistry

Published on: October 20, 2019

Area of Science:

Ophthalmology
Microbiology
Infectious Diseases

Background:

Corynebacterium species are common, typically non-pathogenic inhabitants of the human conjunctiva.
Recent reports indicate potential pathogenicity of Corynebacterium in various tissues, including the eye.

Purpose of the Study:

To investigate Corynebacterium species on the ocular surface.
To review antimicrobial susceptibility and molecular resistance mechanisms of ocular Corynebacterium.

Main Methods:

Literature review of Corynebacterium species, antimicrobial susceptibility, and resistance mechanisms.
Identification of risk factors for Corynebacterium-related ocular infections.

Main Results:

Identified risk factors including poor immunity (diabetes, topical steroid use) and corneal damage (trauma, contact lens wear).
C. macginleyi was the predominant conjunctival strain; several species were linked to keratitis and conjunctivitis.
Ocular Corynebacterium showed quinolone resistance, unlike more susceptible nasal strains. Fluoroquinolone resistance remained stable, but susceptibility to third-generation cephems persisted.

Conclusions:

Third-generation cephems represent a rational and practical treatment choice for ocular infections caused by Corynebacterium species.