Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mitral Stenosis III: Medical Management

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Morphological parameters contributing to aneurysm rupture: Identifying the rogue from the mugshot using different statistical methods.

British journal of neurosurgery·2026

Same author

Robotic assisted-coronary artery bypass grafting (CABG): as safe as CABG, but is recovery better?

Indian journal of thoracic and cardiovascular surgery·2026

Same author

Pathogenic PF4/Polyanion ELISA-Negative Antibodies in HIT.

American journal of hematology·2026

Same author

Non-surgical casting versus surgical reduction for children with severely displaced distal radial fractures (the CRAFFT Study): a multicentre, randomised, controlled non-inferiority trial and economic evaluation.

Lancet (London, England)·2026

Same author

Switching to doravirine-based antiretroviral therapy without genotypic resistance tests in virologically suppressed people with HIV.

AIDS (London, England)·2026

Same author

SHORTER trial: protocol for a pragmatic, multicentre, randomised controlled trial of short-duration antibiotic therapy for critically ill patients with sepsis.

BMJ open·2026

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

Mini-sternotomy versus conventional sternotomy for aortic valve replacement: a randomised controlled trial.

Helen C Hancock¹, Rebecca H Maier¹, Adetayo Kasim²

¹Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK.

|January 30, 2021

Summary

Manubrium-limited mini-sternotomy did not reduce red blood cell transfusions for aortic valve replacement (AVR) patients compared to conventional sternotomy. While mini-sternotomy reduced chest drain losses, it did not improve transfusion rates or cost-effectiveness.

Keywords:

adult intensive & critical care adult surgery cardiac surgery clinical trials health economics

More Related Videos

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

Published on: March 26, 2018

Related Experiment Videos

Last Updated: Jun 12, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

Published on: March 26, 2018

Area of Science:

Cardiovascular Surgery
Thoracic Surgery
Minimally Invasive Surgery

Background:

Conventional median sternotomy is the standard surgical approach for aortic valve replacement (AVR).
Manubrium-limited mini-sternotomy offers a less invasive alternative, potentially reducing complications.
Comparative data on clinical and economic outcomes are crucial for surgical decision-making.

Purpose of the Study:

To compare clinical and health economic outcomes between manubrium-limited mini-sternotomy and conventional median sternotomy for AVR.
To evaluate the impact of surgical approach on red blood cell transfusion rates, quality of life, and cost-effectiveness.

Main Methods:

A single-blind, randomised controlled trial was conducted at a UK National Health Service tertiary hospital.
270 adult patients undergoing AVR were randomised to either manubrium-limited mini-sternotomy or conventional median sternotomy.
Primary outcome was red cell transfusion within 7 days; secondary outcomes included blood component transfusion, quality of life, and cost-effectiveness.

Main Results:

No significant difference in red cell transfusion rates within 7 days was observed between the mini-sternotomy and conventional sternotomy groups (23/135 in each).
Mini-sternotomy led to reduced chest drain losses but did not decrease red cell transfusions.
Longer bypass and cross-clamp times were noted with mini-sternotomy, and conventional sternotomy was found to be more cost-effective.

Conclusions:

Manubrium-limited mini-sternotomy for AVR did not reduce the need for red blood cell transfusions within 7 days compared to conventional sternotomy.
Despite reduced chest drain losses, the mini-sternotomy approach did not demonstrate superior clinical or economic benefits in this study.
Conventional sternotomy remains a more cost-effective option for AVR in this context.