Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Dietary intervention of mice using an improved Multiple Artificial-gravity Research System (MARS) under artificial 1 g.

NPJ microgravity·2026
Same author

0.33<i>g</i> mitigates muscle atrophy while 0.67<i>g</i> preserves muscle function and myofiber type composition in mice during spaceflight.

Science advances·2026
Same author

Bone mineral loss damages renal tubules in mice.

Communications biology·2026
Same author

Impact of microgravity and lunar gravity on murine skeletal and immune systems during space travel.

Scientific reports·2024
Same author

Release of CD36-associated cell-free mitochondrial DNA and RNA as a hallmark of space environment response.

Nature communications·2024
Same author

Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction.

Nature communications·2024

Related Experiment Video

Updated: Nov 19, 2025

Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents
14:02

Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents

Published on: June 29, 2014

23.2K

Study of mouse behavior in different gravity environments.

Michihiko Shimomura1,2, Akane Yumoto1,2, Naoko Ota-Murakami3

  • 1Mouse Epigenetics Project, ISS/Kibo Experiment, Japan Aerospace Exploration Agency, Tsukuba, Japan.

Scientific Reports
|January 30, 2021
PubMed
Summary

Organism behavior adapts to gravity changes over time. A new Active Inactive Separation (AIS) method effectively quantifies this adaptation in space environments.

More Related Videos

Behavioral Assessment of the Aging Mouse Vestibular System
09:30

Behavioral Assessment of the Aging Mouse Vestibular System

Published on: July 11, 2014

17.3K
Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation
06:18

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation

Published on: February 7, 2020

8.4K

Related Experiment Videos

Last Updated: Nov 19, 2025

Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents
14:02

Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents

Published on: June 29, 2014

23.2K
Behavioral Assessment of the Aging Mouse Vestibular System
09:30

Behavioral Assessment of the Aging Mouse Vestibular System

Published on: July 11, 2014

17.3K
Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation
06:18

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation

Published on: February 7, 2020

8.4K

Area of Science:

  • Space biology
  • Animal behavior analysis
  • Gravitational biology

Background:

  • Limited understanding of how organisms behave under altered gravity.
  • Need for quantitative methods to assess behavioral responses in space experiments.

Purpose of the Study:

  • To develop and validate a simple Active Inactive Separation (AIS) method for analyzing organism behavior in space.
  • To investigate the adaptation of organism activity to changes in gravitational conditions, including hypergravity and microgravity.

Main Methods:

  • Development of the Active Inactive Separation (AIS) method to quantify activity and inactivity from habitat cage videos.
  • Calculation of activity ratio and active intervals to assess behavioral changes.
  • Analysis of adaptation to hypergravity (HG) and artificial gravity (AG) from microgravity (MG).

Main Results:

  • The AIS method demonstrated effectiveness, with ground control results aligning with previous studies.
  • Organisms showed a low activity ratio upon initial exposure to hypergravity, with rapid recovery within the first week.
  • A stable activity period was observed after approximately two weeks, indicating adaptation to altered gravity.

Conclusions:

  • The Active Inactive Separation (AIS) method is a viable tool for analyzing organism behavior in altered gravity.
  • Organisms require a period of time to adapt to changes in gravitational environments, whether increasing or decreasing.
  • Behavioral adaptation to hypergravity and microgravity follows a similar time course.