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Cerebral infarction does not occur typically at night.

C van der Windt1, J van Gijn

  • 1University Department of Neurology, Utrecht, The Netherlands.

Journal of Neurology, Neurosurgery, and Psychiatry
|January 1, 1988
PubMed
Summary

Most cerebral infarctions occur during the day, not at night. This study on non-progressive cerebral infarction found few nighttime cases, challenging theories linking atherothrombotic brain infarction to hemodynamic factors.

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Area of Science:

  • Neurology
  • Cerebrovascular Diseases
  • Medical Research

Background:

  • Cerebral infarction, a significant cause of disability, has unclear etiological factors.
  • Previous hypotheses suggested hemodynamic factors influence atherothrombotic brain infarction, particularly concerning the timing of onset.
  • Understanding the temporal patterns of stroke onset is crucial for elucidating underlying mechanisms.

Purpose of the Study:

  • To retrospectively investigate the time of onset and types of cerebral infarction in a hospital-based patient cohort.
  • To evaluate the association between the timing of cerebral infarction and potential etiological factors, specifically hemodynamic influences.

Main Methods:

  • Retrospective analysis of 66 consecutive patients diagnosed with non-progressive cerebral infarction.
  • Computed tomography (CT) scans were used to determine the type and characteristics of the infarction.
  • Data on the time of symptom onset was collected and analyzed for temporal patterns.

Main Results:

  • A significant majority of cerebral infarction cases (78%) occurred between 6 am and 6 pm.
  • Only a small percentage of infarcts (8%) happened between midnight and 6 am.
  • Watershed-infarcts, a specific type of cerebral infarction, were exclusively observed during daytime hours.

Conclusions:

  • The observed diurnal pattern of cerebral infarction does not align with the hypothesis that atherothrombotic brain infarction is primarily driven by hemodynamic factors.
  • The findings suggest that other etiological mechanisms may play a more significant role in the timing of cerebral infarction.
  • Further research is warranted to explore alternative factors influencing the circadian rhythm of stroke.

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