Related Experiment Video
Updated: Nov 19, 2025
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
F-18 FDG PET/CT and F-18 FLT PET/CT as predictors of outcome in patients with multiple myeloma. A pilot study
R Gallicchio1, A Nardelli2, G Calice3
1Medicina Nucleare, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Centro di Riferimento Oncologico di Basilicata (CROB), Rionero in Vulture, Italy.
Objectives:
We evaluated the prognostic significance of the combined use of F-18 FDG (FDG) and F-18 FLT (FLT) PET/CT (PET/CT) in patients (pts) with multiple myeloma (MM) suspected relapse after a first line chemotherapy.
Methods:
twenty-eight patients (57 ± 12 years) underwent both PET/CT scans over 2-4 weeks. Patients were grouped according to imaging results (FDG+/-; FLT+/-) and the findings compared to the event free survival (EFS).
Results:
five pts had FDG+; FLT+, 8 showed FDG+;FLT-, two had FDG-;FLT + and 13 presented FDG-;FLT-, mostly (87 %) of FDG+;FLT- pts had destructive lytic bone lesions. At Cox regression analysis the FDG PET/CT (HR 4.4, 95 % CI 1.3-15.4, p < 0.05) and FLT PET/CT (HR 5.8, 95 % CI 1.7-19.3, p < 0.01) were predictive of worst prognosis. The Kaplan-Meier analysis showed that FDG and FLT PET/CT independently influenced the survival. FDG-;FLT-patients had better EFS as compared to FDG+; FLT + pts and FDG-;FLT + pts, those of FDG+;FLT- group also had worsened EFS.
Conclusions:
results from the aggregate use of PET/CT FDG and FLT in MM represent a valuable prognostic indicator for identifying patients at higher risk of undue events and may help to correctly stratify the patients with suspected relapse.
Insights
Combined F-18 FDG and F-18 FLT PET/CT scans offer prognostic value in multiple myeloma (MM) relapse. These imaging techniques help identify patients with a higher risk of adverse events, aiding in better patient stratification.
Area of Science:
- Nuclear Medicine
- Oncology
- Radiomics
Background:
- Multiple Myeloma (MM) relapse after initial chemotherapy poses a significant clinical challenge.
- Accurate prognostic tools are crucial for stratifying patients and guiding treatment decisions.
- Positron Emission Tomography/Computed Tomography (PET/CT) offers functional imaging insights.
Purpose of the Study:
- To evaluate the prognostic significance of combined F-18 FDG (FDG) and F-18 FLT (FLT) PET/CT in patients with suspected MM relapse.
- To determine if dual-tracer PET/CT can identify patients at higher risk of adverse events.
- To assess the utility of FDG and FLT PET/CT in patient stratification post-chemotherapy.
Main Methods:
- Twenty-eight patients with suspected MM relapse underwent both FDG PET/CT and FLT PET/CT scans within a 2-4 week interval.
- Patients were categorized based on FDG and FLT uptake (FDG+/-, FLT+/-).
- Event-free survival (EFS) was compared across different imaging groups using Cox regression and Kaplan-Meier analyses.
Main Results:
- FDG PET/CT and FLT PET/CT independently predicted a worse prognosis (FDG PET/CT: HR 4.4, p < 0.05; FLT PET/CT: HR 5.8, p < 0.01).
- Patients with FDG-negative/FLT-negative (FDG-;FLT-) scans generally had better EFS compared to other groups.
- Destructive lytic bone lesions were predominantly observed in the FDG-positive/FLT-negative (FDG+;FLT-) group (87%).
Conclusions:
- The combined use of FDG and FLT PET/CT provides a valuable prognostic indicator in multiple myeloma.
- This dual-tracer approach effectively identifies patients at higher risk of adverse events.
- Aggregate PET/CT findings aid in accurate patient stratification for suspected relapsed MM.
More Related Videos
10:04Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
07:54Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
