Related Experiment Video
Updated: Nov 19, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
PARP Inhibitors in Prostate Cancer
Kabir Grewal1, Kayanaat Grewal2, Imad A Tabbara3
1Florida State University College of Medicine, Tallahassee, FL, U.S.A.
Poly-ADP-ribose polymerase (PARP) inhibitors represent a breakthrough in treating metastatic prostate cancer for patients with specific genetic mutations. This review examines three PARP inhibitors showing significant promise in improving patient outcomes.
Area of Science:
- Oncology
- Genetics
- Pharmacology
Background:
- Metastatic prostate cancer treatment has historically relied on androgen deprivation, chemotherapy, and radiation.
- Recent advancements include targeted therapies based on genetic profiling.
Purpose of the Study:
- To review the role and efficacy of poly-ADP-ribose polymerase (PARP) inhibitors in metastatic prostate cancer.
- To focus on three specific PARP inhibitors demonstrating activity in this patient population.
Main Methods:
- Literature review of clinical studies and research on PARP inhibitors in metastatic prostate cancer.
- Analysis of treatment outcomes for patients with specific genetic mutations.
Main Results:
- Poly-ADP-ribose polymerase (PARP) inhibitors have shown significant improvements in outcomes for select metastatic prostate cancer patients.
- Three PARP inhibitors have demonstrated notable activity and efficacy.
Conclusions:
- PARP inhibitors are a significant advancement in the evolving landscape of metastatic prostate cancer therapy.
- Targeted therapy with PARP inhibitors offers new hope for patients with specific genetic alterations.
More Related Videos
07:13Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control
Published on: May 24, 2024
12:13Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
Published on: November 19, 2019
Related Concept Videos
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Inhibition of Cdk Activity
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...