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Updated: Nov 19, 2025

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Metastatic renal cell carcinoma extending to the left atrium through the inferior pulmonary vein
Alan G Dawson1, Cathy J Richards2, Leonidas Hadjinikolaou3
1Department of Thoracic Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.
Abstract:
Metastatic renal cell carcinoma with involvement through the pulmonary veins to the left atrium is very rare. We report the case of a 70-year-old male with metastatic renal cell carcinoma to the right lower lobe of the lung abutting the inferior pulmonary vein with extension to the left atrium without pre-operative evidence. Surgical resection was achieved through a posterolateral thoracotomy. Lung masses that abut the pulmonary veins should prompt further investigation with a pre-operative transoesophageal echocardiogram to minimize unexpected intraoperative findings.
Insights
Metastatic renal cell carcinoma rarely involves the pulmonary veins and left atrium. Early detection via transesophageal echocardiogram is crucial for lung masses near pulmonary veins to prevent surgical surprises.
Area of Science:
- Cardiology
- Oncology
- Thoracic Surgery
Background:
- Metastatic renal cell carcinoma (RCC) is a complex malignancy.
- Pulmonary vein and left atrial involvement by metastatic RCC is exceptionally rare.
- Surgical management of thoracic metastases requires careful pre-operative assessment.
Observation:
- A 70-year-old male presented with metastatic renal cell carcinoma.
- The tumor involved the right lower lobe lung mass, abutting the inferior pulmonary vein.
- Tumor extension into the left atrium was identified intraoperatively without prior evidence.
Findings:
- The metastatic lung mass extended through the pulmonary vein into the left atrium.
- Surgical resection was successfully performed via posterolateral thoracotomy.
- Pre-operative imaging failed to detect the intracardiac extension.
Implications:
- Lung masses adjacent to pulmonary veins necessitate thorough pre-operative evaluation.
- Transesophageal echocardiography is recommended for assessing potential vascular and intracardiac invasion.
- This case highlights the importance of advanced imaging in surgical planning for metastatic disease.
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