COVID-19 in Pediatric Patients: Observations from the Initial Phase of the Global Pandemic in Rhode Island

Rebecca A Levin1, Hoi See Tsao1, Siraj Amanullah2

  • 1Department of Emergency Medicine, Department of Pediatrics, Brown University School of Public Health, Warren Alpert Medical School of Brown University, Providence, RI.

Insights

During the initial COVID-19 wave, 11% of children tested in Rhode Island were positive for SARS-CoV-2. Hispanic children were disproportionately affected, highlighting a need for targeted public health support.

Area of Science:

  • Pediatric infectious diseases
  • Epidemiology of viral infections
  • Public health surveillance

Background:

  • The initial wave of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infections presented unique challenges for pediatric populations.
  • Understanding the characteristics of children tested for SARS-CoV-2 is crucial for effective public health response.

Purpose of the Study:

  • To characterize children undergoing SARS-CoV-2 testing during the early phase of the pandemic in Rhode Island.
  • To identify demographic and symptomatic patterns among pediatric cases.

Main Methods:

  • A descriptive study was conducted involving 729 children tested for SARS-CoV-2.
  • Data was collected from four emergency departments in Rhode Island between April 9 and May 7, 2020.
  • Demographic information and symptom data were systematically cataloged.

Main Results:

  • Out of 729 children tested, 81 (11%) tested positive for SARS-CoV-2.
  • A high percentage of positive children (94%) were symptomatic, with common symptoms including constitutional (74%) and upper respiratory (72%).
  • Hispanic children represented 34% of those tested but accounted for 68% of positive SARS-CoV-2 cases.

Conclusions:

  • The study provides insights into the pediatric experience during the first SARS-CoV-2 wave in Rhode Island.
  • Findings can inform testing strategies and resource allocation in healthcare settings.
  • The disproportionate impact on Hispanic children underscores the need for targeted public health interventions and support.
Abstract

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
128
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
102
Assessment of Respiration01:23

Assessment of Respiration

The respiratory system's basic structures and primary functions lay the foundation for nurses' comprehensive respiratory assessments. This assessment includes subjective and objective data to gauge the patient's respiratory health.
Subjective Assessment: Nurses interview the patient to gather information directly during the subjective assessment. It includes questions about the individual's medical history, medications, and symptoms, focusing on past respiratory conditions like...
1.6K
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
89
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
106
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
2.5K